Mitogen-activated protein kinase kinase kinase 7 (Q21157667)

http://www.ebi.ac.uk/interpro/protein/O43318

mitogen-activated protein (MAP) kinase kinase kinase 7

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43318

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

SASH1 is a scaffold molecule in endothelial TLR4 signaling

scaffold protein binding

1 reference

1 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

protein serine/threonine kinase activity

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

24 references

1 January 2018

IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Inhibition of autophagy by TAB2 and TAB3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1-dependent signaling requires functional interaction with TAB2/TAB3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

2 references

magnesium ion binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

MAP kinase kinase kinase activity

5 references

31 October 2017

Molecular cloning of human TAK1 and its mutational analysis in human lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

31 October 2017

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

31 October 2017

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

identical protein binding

EXP

1 reference

1 January 2018

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

MAP kinase kinase kinase activity

IPI

6 references

1 January 2018

Molecular cloning of human TAK1 and its mutational analysis in human lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

receptor tyrosine kinase binding

EXP

1 reference

1 January 2018

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

31 October 2017

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

IkappaB kinase complex

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

regulation of transcription, DNA-templated

HDA

biological process

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

stimulatory C-type lectin receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

activation of NF-kappaB-inducing kinase activity

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

I-kappaB phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

MyD88-dependent toll-like receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

transcription, DNA-templated

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

Fc-epsilon receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

protein phosphorylation

1 reference

1 January 2018

positive regulation of T cell activation

1 reference

31 October 2017

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

positive regulation of NF-kappaB transcription factor activity

IC

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

positive regulation of interleukin-2 production

1 reference

1 January 2018

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

positive regulation of T cell cytokine production

1 reference

1 January 2018

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein

histone H3 acetylation

1 reference

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

31 October 2017

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

I-kappaB kinase/NF-kappaB signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

transforming growth factor beta receptor signaling pathway

1 reference

1 January 2018

Molecular cloning of human TAK1 and its mutational analysis in human lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

nucleotide-binding oligomerization domain containing signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

Wnt signaling pathway, calcium modulating pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

stress-activated MAPK cascade

1 reference

1 January 2018

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

positive regulation of macroautophagy

1 reference

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

ISS

protein deubiquitination

1 reference

1 January 2018

1 reference

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

MyD88-independent toll-like receptor signaling pathway

ISS

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43318&geneProductId=UniProtKB:O43318

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

positive regulation of I-kappaB kinase/NF-kappaB signaling

IBA

interleukin-1-mediated signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43318

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016