Protein tyrosine phosphatase non-receptor type 1 (Q21171691)

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mammalian protein found in Homo sapiens
  • PTP-1B
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • protein tyrosine phosphatase, placental
  • protein-tyrosine phosphatase 1B
  • tyrosine-protein phosphatase non-receptor type 1
  • PTPN1
edit
Language Label Description Also known as
English
Protein tyrosine phosphatase non-receptor type 1
mammalian protein found in Homo sapiens
  • PTP-1B
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • protein tyrosine phosphatase, placental
  • protein-tyrosine phosphatase 1B
  • tyrosine-protein phosphatase non-receptor type 1
  • PTPN1

Statements

molecular function
protein binding
determination method
IPI
59 references
retrieved
8 April 2019
stated in
PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
The role of protein-tyrosine phosphatase 1B in integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein tyrosine phosphatases associating with the PDGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Reactivation of oxidized PTP1B and PTEN by thioredoxin 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PTP-1B is an essential positive regulator of platelet integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Identification of tyrosines in the putative regulatory site of the Ca2+ channel TRPV6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphatase PTP1B interacts with TRPV6 in vivo and plays a role in TRPV6-mediated calcium influx in HEK293 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PTP1B regulates leptin signal transduction in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Monitoring phosphatase reactions of multiple phosphorylated substrates by reversed-phase HPLC
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein tyrosine phosphatase 1B by sumoylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
PTPIP51-a myeloid lineage specific protein interacts with PTP1B in neutrophil granulocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IPI
protein tyrosine phosphatase activity
determination method
IDA
TAS
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P18031
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IEA
retrieved
8 April 2019
stated in
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response
GOA
curator
UniProt
UniProt protein ID
P18031
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IDA
retrieved
8 April 2019
stated in
Thionein/metallothionein control Zn(II) availability and the activity of enzymes
GOA
curator
UniProt
UniProt protein ID
P18031
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IDA
retrieved
8 April 2019
stated in
Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18031
determination method
IDA
cell component
biological process

Identifiers

MeSH descriptor ID
D054562
subject named as
Protein Tyrosine Phosphatase, Non-Receptor Type 1
1 reference
reference URL
https://meshb.nlm.nih.gov/#/record/ui?ui=D054562
PDB structure ID
 
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