Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment (Q21245749)

Dimensions

1015633806

19 August 2022

Hong Zhe

series ordinal

2

author given names

Hong

author last names

Zhe

1 reference

Dimensions

1015633806

19 August 2022

Ren Zhao

series ordinal

3

author given names

Ren

author last names

Zhao

1 reference

Dimensions

1015633806

Creative Commons Attribution 2.0 Generic

19 August 2022

language of work or name

English

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publication date

20 February 2014

4 references

3 April 2019

7 November 2019

14 September 2020

8 February 2021

4 references

3 April 2019

7 November 2019

14 September 2020

8 February 2021

13

0 references

issue

1

0 references

page(s)

30

0 references

copyright license

4 references

3 April 2019

7 November 2019

14 September 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-30

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-30

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Telomerase reverse transcriptase (TERT) is a therapeutic target of oleanane triterpenoid CDDO-Me in prostate cancer

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Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent

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ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid CDDO-Me in ovarian cancer cells

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Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.

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Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity

12 September 2017

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Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling

12 September 2017

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Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer

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Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer

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CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.

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CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer

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Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells.

12 September 2017

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Triterpenoids for cancer prevention and treatment: current status and future prospects

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Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling

12 September 2017

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Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a

12 September 2017

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Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

12 September 2017

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Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells

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Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

12 September 2017

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12 September 2017

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Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR

12 September 2017

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Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

12 September 2017

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CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells

12 September 2017

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Inflammation: gearing the journey to cancer

12 September 2017

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Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

12 September 2017

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Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals

12 September 2017

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

12 September 2017

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12 September 2017

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Beginning to understand the end of the chromosome

12 September 2017

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Plant-derived triterpenoids as potential antineoplastic agents

12 September 2017

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Chromosome first aid.

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CDDO-Me inhibits proliferation, induces apoptosis, down-regulates Akt, mTOR, NF-kappaB and NF-kappaB-regulated antiapoptotic and proangiogenic proteins in TRAMP prostate cancer cells

12 September 2017

1 reference

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c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.

27 September 2017

1 reference

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CDDO-me induces apoptosis and inhibits Akt, mTOR and NF-kappaB signaling proteins in prostate cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3940295

The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-30

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-30

The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-30

21 January 2018

Identifiers

DOI

10.1186/1476-4598-13-30

1 reference

2935368

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-30

1 reference

9 September 2019

2935368

1 reference

1 reference

1 reference