Myeloid cell leukemia sequence 1 (Q21428169)

Apoptosis regulator, Mcl-1

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

10 references

14 February 2019

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Structural insights into the degradation of Mcl-1 induced by BH3 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

BH3 domains other than Bim and Bid can directly activate Bax/Bak

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

protein homodimerization activity

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

protein heterodimerization activity

3 references

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

integral component of membrane

ISO

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

1 reference

14 February 2019

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

4 references

14 February 2019

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

1 reference

24 April 2018

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

5 references

14 February 2019

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Goofy coordinates the acuity of olfactory signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

mitochondrial outer membrane

IDA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

regulation of apoptotic process

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

apoptotic mitochondrial changes

1 reference

24 April 2018

MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

intrinsic apoptotic signaling pathway in response to DNA damage

IDA

1 reference

24 April 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

extrinsic apoptotic signaling pathway in absence of ligand

IDA

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

24 April 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

negative regulation of apoptotic process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

24 April 2018

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97287&geneProductId=UniProtKB:P97287

negative regulation of intrinsic apoptotic signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

negative regulation of apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

extrinsic apoptotic signaling pathway in absence of ligand

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

1 reference

Commons category

Myeloid cell leukemia sequence 1 protein

0 references

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016