Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 (Q24308897)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

positive regulation of oxidative stress-induced neuron death

5 March 2020

main subject

cell biology

0 references

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903223

neuron intrinsic apoptotic signaling pathway in response to oxidative stress

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0036480

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

1 reference

BCL2-associated X protein

1 reference

Myeloid cell leukemia sequence 1

1 reference

F-box and WD-40 domain protein 7

1 reference

Parkin RBR E3 ubiquitin protein ligase

1 reference

author

Michael G Schlossmacher

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Susanna Ekholm-Reed

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Matthew S Goldberg

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Steven I Reed

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

15 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

5 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

3627-3643

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3753862/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

19 March 2017

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

19 March 2017

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19 March 2017

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7 April 2017

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

7 April 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation

27 September 2017

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Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

27 September 2017

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27 September 2017

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27 September 2017

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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

27 September 2017

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27 September 2017

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27 September 2017

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Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease

27 September 2017

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27 September 2017

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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

27 September 2017

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27 September 2017

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

27 September 2017

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27 September 2017

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27 September 2017

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

27 September 2017

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

27 September 2017

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27 September 2017

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SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis

27 September 2017

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mTORC1 promotes survival through translational control of Mcl-1.

27 September 2017

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27 September 2017

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27 September 2017

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Complex I deficiency in Parkinson's disease frontal cortex

27 September 2017

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Fbw7/hCDC4 dimerization regulates its substrate interactions

27 September 2017

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

27 September 2017

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Phenotypic commonalities in familial and sporadic Parkinson disease

27 September 2017

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Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function

27 September 2017

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

27 September 2017

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Pathogenetic mechanisms of parkin in Parkinson's disease

27 September 2017

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

27 September 2017

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

27 September 2017

1 reference

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

27 September 2017

1 reference

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A resource for large-scale RNA-interference-based screens in mammals.

27 September 2017

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

27 September 2017

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The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease.

27 September 2017

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The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

27 September 2017

1 reference

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Mcl-1 deficiency results in peri-implantation embryonic lethality

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Multiple defects of the mitochondrial respiratory chain in a mitochondrial encephalopathy (MERRF): a clinical, biochemical and molecular study.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753862

MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23858059

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/23858059

12 December 2020

inferred from PubMed ID database lookup

Molecular genetic analysis of a novelParkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in theParkin gene in affected individuals

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FMCB.00535-13

7 January 2021

inferred from DOI database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FMCB.00535-13

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1128/MCB.00535-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858059%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference