Low density lipoprotein receptor-related protein 6 (Q21495922)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88572

LDL receptor-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88572

Six-bladed beta-propeller, TolB-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88572

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

LDLR class B repeat, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

coreceptor activity involved in Wnt signaling pathway

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Wnt-activated receptor activity

1 reference

9 August 2016

signaling receptor binding

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

kinase inhibitor activity

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

protein homodimerization activity

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

10 references

9 August 2016

8 April 2019

Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

low-density lipoprotein particle receptor activity

IPI

identical protein binding

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

apolipoprotein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Wnt-activated receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

cell component

endoplasmic reticulum

1 reference

8 April 2019

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Wnt-Frizzled-LRP5/6 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88572&geneProductId=UniProtKB:O88572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

4 references

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88572&geneProductId=UniProtKB:O88572

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88572&geneProductId=UniProtKB:O88572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Wnt signaling pathway involved in forebrain neuroblast division

biological process

3 references

9 August 2016

8 April 2019

Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

receptor-mediated endocytosis involved in cholesterol transport

1 reference

9 August 2016

embryonic pattern specification

1 reference

9 August 2016

axis elongation involved in somitogenesis

1 reference

9 August 2016

positive regulation of canonical Wnt signaling pathway

1 reference

9 August 2016

negative regulation of Wnt signaling pathway

1 reference

9 August 2016

odontogenesis of dentin-containing tooth

1 reference

9 August 2016

external genitalia morphogenesis

1 reference

9 August 2016

embryonic retina morphogenesis in camera-type eye

1 reference

9 August 2016

1 reference

9 August 2016

primitive streak formation

1 reference

9 August 2016

cerebellum morphogenesis

1 reference

9 August 2016

3 references

9 August 2016

8 April 2019

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

branching involved in mammary gland duct morphogenesis

1 reference

9 August 2016

1 reference

9 August 2016

embryonic digit morphogenesis

cellular response to cholesterol

IMP

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

positive regulation of transcription, DNA-templated

IDA

midbrain-hindbrain boundary development

1 reference

9 August 2016

positive regulation of cell cycle

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

embryonic limb morphogenesis

1 reference

9 August 2016

embryonic camera-type eye morphogenesis

1 reference

9 August 2016

pericardium morphogenesis

1 reference

9 August 2016

post-anal tail morphogenesis

4 references

9 August 2016

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

protein localization to plasma membrane

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

negative regulation of protein phosphorylation

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Wnt signaling pathway involved in somitogenesis

1 reference

9 August 2016

roof of mouth development

1 reference

9 August 2016

negative regulation of protein kinase activity

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

9 August 2016

positive regulation of DNA-binding transcription factor activity

1 reference

9 August 2016

neural crest cell differentiation

1 reference

9 August 2016

trachea cartilage morphogenesis

1 reference

9 August 2016

cerebral cortex development

1 reference

9 August 2016

canonical Wnt signaling pathway

14 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

negative regulation of protein serine/threonine kinase activity

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

embryonic forelimb morphogenesis

5 references

9 August 2016

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

9 August 2016

positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

1 reference

9 August 2016

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

gastrulation with mouth forming second

1 reference

9 August 2016

Wnt signaling pathway

1 reference

9 August 2016

multicellular organism development

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

1 reference

9 August 2016

1 reference

9 August 2016

Wnt signaling pathway involved in dorsal/ventral axis specification

1 reference

9 August 2016

negative regulation of smooth muscle cell apoptotic process

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

anterior/posterior pattern specification

1 reference

9 August 2016

positive regulation of transcription by RNA polymerase II

1 reference

9 August 2016

embryonic hindlimb morphogenesis

4 references

9 August 2016

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

2 references

9 August 2016

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

chemical synaptic transmission

1 reference

9 August 2016

Crooked tail (Cd) models human folate-responsive neural tube defects

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

anterior/posterior pattern specification

4 references

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

positive regulation of neuron projection development

1 reference

8 April 2019

Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

midbrain-hindbrain boundary development

3 references

8 April 2019

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genetic interaction between Lrp6 and Wnt5a during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

odontogenesis of dentin-containing tooth

3 references

8 April 2019

Tooth development in the 'crooked' mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Genes and genotypes affecting the teeth of the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

embryonic camera-type eye morphogenesis

3 references

8 April 2019

Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

positive regulation of DNA-binding transcription factor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

roof of mouth development

3 references

8 April 2019

Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

embryonic retina morphogenesis in camera-type eye

3 references

8 April 2019

Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

Norrin signaling pathway

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88572