The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin (Q24310488)

toxin transmembrane transporter activity

GOA release 2020-03-11

1 reference

Low density lipoprotein receptor-related protein 6

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

4

Stephen H Leppla

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author name string

Wensheng Wei

1

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Quan Lu

2

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G Jilani Chaudry

3

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Stanley N Cohen

Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

5

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language of work or name

English

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publication date

24 March 2006

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published in

Cell

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volume

124

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page(s)

1141-54

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issue

6

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cites work

1 reference

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Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

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LDL receptor relatives at the crossroad of endocytosis and signaling.

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Production and purification of anthrax toxin

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding

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The LDL receptor gene family: signaling functions during development.

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

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An LDL-receptor-related protein mediates Wnt signalling in mice

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Identification of the cellular receptor for anthrax toxin

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

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Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages

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EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin

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Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

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TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

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Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

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Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100

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TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes

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Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates

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Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

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The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

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Generation and analysis of 280,000 human expressed sequence tags

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A system for stable expression of short interfering RNAs in mammalian cells

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Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

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Transcriptional activation by tetracyclines in mammalian cells

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Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP.

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A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

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Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

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Anthrax toxin: structures, functions and tumour targeting

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