Nuclear factor, erythroid derived 2,-like 1 (Q21496622)

Nuclear factor erythroid 2-related factor 1/NFE2L1

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Basic leucine zipper domain, Maf-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

1 reference

27 March 2018

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

14 February 2019

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

protein binding

1 reference

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

protein domain specific binding

1 reference

14 February 2019

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

RNA polymerase II cis-regulatory region sequence-specific DNA binding

Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1

6 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

DNA-binding transcription activator activity, RNA polymerase II-specific

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

4 references

27 March 2018

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

DNA-binding transcription repressor activity, RNA polymerase II-specific

2 references

cholesterol binding

1 reference

14 February 2019

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

lipid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

protein-containing complex binding

1 reference

14 February 2019

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

transcription cis-regulatory region binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

chromatin binding

1 reference

14 February 2019

Induction of Herpud1 expression by ER stress is regulated by Nrf1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

promoter-specific chromatin binding

1 reference

14 February 2019

Induction of Herpud1 expression by ER stress is regulated by Nrf1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

1 reference

1 January 2018

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

1 reference

1 January 2018

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

nucleus

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

7 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

Ensembl genome database project

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

integral component of endoplasmic reticulum membrane

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

protein-containing complex

1 reference

14 February 2019

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

3 references

14 February 2019

14 February 2019

The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

erythrocyte differentiation

biological process

1 reference

14 February 2019

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

negative regulation of transcription by RNA polymerase II

1 reference

27 March 2018

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

cellular response to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

3 references

27 March 2018

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

positive regulation of transcription from RNA polymerase II promoter in response to stress

3 references

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

cell redox homeostasis

2 references

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

lipid homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

1 reference

27 March 2018

cellular response to cholesterol

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

negative regulation of transcription from RNA polymerase II promoter in response to stress

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

regulation of odontoblast differentiation

1 reference

27 March 2018

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

1 reference

27 March 2018

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

cholesterol homeostasis

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61985&geneProductId=UniProtKB:Q61985

cellular response to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

1 reference

14 February 2019

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

protein polyubiquitination

1 reference

14 February 2019

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

fructose 6-phosphate metabolic process

1 reference

14 February 2019

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of transcription by RNA polymerase II

The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Induction of Herpud1 expression by ER stress is regulated by Nrf1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Induction of Herpud1 expression by ER stress is regulated by Nrf1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

glutathione metabolic process

1 reference

14 February 2019

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of mitotic nuclear division

1 reference

14 February 2019

Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of gene expression

3 references

14 February 2019

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

14 February 2019

Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of glucose metabolic process

1 reference

14 February 2019

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of lipid metabolic process

1 reference

14 February 2019

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of fatty acid metabolic process

1 reference

14 February 2019

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

cellular homeostasis

1 reference

14 February 2019

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

spinal cord motor neuron differentiation

1 reference

14 February 2019

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

glial cell fate commitment

1 reference

14 February 2019

Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

response to endoplasmic reticulum stress

cholesterol homeostasis

1 reference

14 February 2019

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

cysteine transport

1 reference

14 February 2019

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

glucose 6-phosphate metabolic process

1 reference

14 February 2019

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of proteasomal protein catabolic process

cellular response to cold

1 reference

14 February 2019

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

cellular response to cholesterol

1 reference

14 February 2019

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of nucleus organization

1 reference

14 February 2019

Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

regulation of response to endoplasmic reticulum stress

1 reference

14 February 2019

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61985

Basic-leucine zipper domain

has part(s)

1 reference

Basic leucine zipper domain, Maf-type

1 reference