Axin 1 (Q21981220)

Axin-1

1 reference

RGS domain superfamily

1 reference

RGS, subdomain 1/3

1 reference

DIX domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

DIX domain, protein family

1 reference

Axin beta-catenin binding domain, protein family

1 reference

Axin-1/2, tankyrase-binding domain, protein family

1 reference

Regulator of G protein signalling

1 reference

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

1 reference

25 May 2022

1 reference

25 May 2022

26 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

protein homodimerization activity

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

signaling receptor complex adaptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

GTPase activator activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

protein self-association

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

Functional domains of axin. Importance of the C terminus as an oligomerization domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

molecular adaptor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

ubiquitin protein ligase binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

signaling receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

protein kinase binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

protein domain specific binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

armadillo repeat domain binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

8 April 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

8 April 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

8 April 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

signaling adaptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

perinuclear region of cytoplasm

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

lateral plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

cytoplasmic microtubule

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

5 references

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

beta-catenin destruction complex

4 references

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

protein-containing complex

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

6 references

9 May 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

biological process

axial mesoderm formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

nucleocytoplasmic transport

1 reference

9 May 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

protein catabolic process

1 reference

9 May 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

axial mesoderm development

1 reference

9 May 2019

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

cytoplasmic microtubule organization

1 reference

9 May 2019

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

regulation of protein phosphorylation

IGI

1 reference

9 May 2019

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

negative regulation of protein metabolic process

IGI

1 reference

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

negative regulation of fat cell differentiation

1 reference

9 May 2019

Inhibition of adipogenesis by Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

post-anal tail morphogenesis

1 reference

9 May 2019

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

embryonic eye morphogenesis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

positive regulation of JNK cascade

forebrain anterior/posterior pattern specification

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

lens placode formation

1 reference

24 April 2018

Wnt-activated signaling pathway involved in forebrain neuron fate commitment

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

protein polyubiquitination

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination of left/right symmetry

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

positive regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

muscle cell development

1 reference

24 April 2018

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of peptidyl-threonine phosphorylation

1 reference

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

sensory perception of sound

1 reference

9 May 2019

A case of neighboring loci with similar effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

olfactory placode formation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

activation of protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of transforming growth factor beta receptor signaling pathway

3 references

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

negative regulation of Wnt signaling pathway

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

negative regulation of canonical Wnt signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of JUN kinase activity

4 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

dorsal/ventral pattern formation

positive regulation of protein ubiquitination

3 references

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of GTPase activity

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

negative regulation of gene expression

1 reference

9 May 2019

Putative tumor suppressor EDD interacts with and up-regulates APC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

1 reference

9 May 2019

Generation of Axin1 conditional mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

regulation of canonical Wnt signaling pathway

1 reference

9 May 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

Wnt signaling pathway

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

24 April 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Wnt signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

negative regulation of Wnt signaling pathway

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

positive regulation of JNK cascade

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625