Dishevelled segment polarity protein 2 (Q21981319)

Ubiquitin-like domain superfamily

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

Winged helix DNA-binding domain superfamily

1 reference

PDZ superfamily

1 reference

DIX domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

DIX domain, protein family

1 reference

Dishevelled

1 reference

PDZ domain, protein family

1 reference

Dishevelled C-terminal domain, protein family

1 reference

DEP domain, protein family

1 reference

protein-macromolecule adaptor activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

protein domain specific binding

1 reference

14 February 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

Molecular basis of Wnt activation via the DIX domain protein Ccd1

protein self-association

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

16 references

14 February 2019

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Structural Analysis of the Interaction between Dishevelled2 and Clathrin AP-2 Adaptor, A Critical Step in Noncanonical Wnt Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Diversin regulates heart formation and gastrulation movements in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Mechanism of activation of the Formin protein Daam1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

IPI

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

identical protein binding

IPI

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

8 references

14 February 2019

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dynamic recruitment of axin by Dishevelled protein assemblies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

6 references

14 February 2019

Dynamic recruitment of axin by Dishevelled protein assemblies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

Wnt-mediated relocalization of dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

3 references

14 February 2019

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling

clathrin-coated vesicle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization

lateral plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

intracellular signal transduction

IBA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

positive regulation of JUN kinase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

positive regulation of canonical Wnt signaling pathway

1 reference

16 July 2018

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

positive regulation of protein tyrosine kinase activity

1 reference

14 February 2019

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

outflow tract morphogenesis

1 reference

14 February 2019

Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Wnt-mediated relocalization of dishevelled proteins

Wnt signaling pathway

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

24 April 2018

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

segment specification

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

planar cell polarity pathway involved in neural tube closure

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Wnt signaling pathway, planar cell polarity pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

positive regulation of GTPase activity

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

1 reference

14 February 2019

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

protein complex oligomerization

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

cochlea morphogenesis

canonical Wnt signaling pathway

8 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Dynamic recruitment of axin by Dishevelled protein assemblies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

16 July 2018

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838

convergent extension involved in neural plate elongation

1 reference

14 February 2019

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

convergent extension involved in organogenesis

1 reference

14 February 2019

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

positive regulation of neuron projection arborization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

Wnt signaling pathway

canonical Wnt signaling pathway

2 references

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Molecular basis of Wnt activation via the DIX domain protein Ccd1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dynamic recruitment of axin by Dishevelled protein assemblies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

planar cell polarity pathway involved in neural tube closure

IBA

3 references

14 February 2019

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838