The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization (Q41791636)

10 October 2017

title

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization (English)

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Dishevelled segment polarity protein 2

10 October 2017

main subject

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GOA release 2020-03-11

author name string

Thomas Schwarz-Romond

1

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10 October 2017

Marc Fiedler

2

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10 October 2017

Naoki Shibata

3

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10 October 2017

P Jonathan G Butler

4

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10 October 2017

Akira Kikuchi

5

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10 October 2017

Yoshiki Higuchi

6

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10 October 2017

Mariann Bienz

7

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10 October 2017

publication date

27 May 2007

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Nature Structural & Molecular Biology

10 October 2017

published in

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10 October 2017

volume

14

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10 October 2017

issue

6

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10 October 2017

page(s)

484-492

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Wnt signaling: a common theme in animal development

10 October 2017

cites work

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Tissue repair and stem cell renewal in carcinogenesis

31 March 2020

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The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal

31 March 2020

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The dishevelled protein is modified by wingless signaling in Drosophila

31 March 2020

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A frizzled homolog functions in a vertebrate Wnt signaling pathway

31 March 2020

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

31 March 2020

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Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation

31 March 2020

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The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

31 March 2020

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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

31 March 2020

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

31 March 2020

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Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

31 March 2020

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

31 March 2020

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Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

31 March 2020

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A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.

31 March 2020

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Human dishevelled genes constitute a DHR-containing multigene family

31 March 2020

1 reference

Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis

31 March 2020

1 reference

MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.

31 March 2020

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DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad

31 March 2020

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Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling

31 March 2020

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The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

31 March 2020

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The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles

31 March 2020

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Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.

31 March 2020

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Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.

31 March 2020

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Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

31 March 2020

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

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The sequences appended to the amyloid core region of the HET-s prion protein determine higher-order aggregate organization in vivo

31 March 2020

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The molecular basis of amyloidosis.

31 March 2020

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Protein secondary structure prediction based on position-specific scoring matrices

31 March 2020

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Functional domains of axin. Importance of the C terminus as an oligomerization domain

31 March 2020

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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

31 March 2020

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Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

31 March 2020

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Cell signaling and function organized by PB1 domain interactions.

31 March 2020

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

31 March 2020

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Frizzled receptor dimerization is sufficient to activate the Wnt/beta-catenin pathway.

31 March 2020

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A mechanism for Wnt coreceptor activation

31 March 2020

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Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world

31 March 2020

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SAM domains: uniform structure, diversity of function

31 March 2020

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Derepression by depolymerization; structural insights into the regulation of Yan by Mae.

31 March 2020

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Polymerization of the SAM domain of MAPKKK Ste11 from the budding yeast: implications for efficient signaling through the MAPK cascades

31 March 2020

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The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

31 March 2020

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Bacterial chromosome segregation: structure and DNA binding of the Soj dimer--a conserved biological switch

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Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases

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Improved methods for fitting sedimentation coefficient distributions derived by time-derivative techniques.

31 March 2020

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

31 March 2020

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Integration of macromolecular diffraction data

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The CCP4 suite: programs for protein crystallography

31 March 2020

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[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

31 March 2020

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

31 March 2020

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB1247

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Dimensions Publication ID

10 October 2017

1010647354

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