Signaling lymphocytic activation molecule family member 1 (Q21983287)

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mammalian protein found in Mus musculus

SLAM family member 1
signaling lymphocytic activation molecule
signaling lymphocyte activation molecule
Slamf1

Language	Label	Description	Also known as
English	Signaling lymphocytic activation molecule family member 1	mammalian protein found in Mus musculus	SLAM family member 1 signaling lymphocytic activation molecule signaling lymphocyte activation molecule Slamf1

Statements

1 reference

25 May 2022

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUM4

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUM4

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Signaling lymphocytic activation molecule, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

5 references

14 February 2019

Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

integral component of membrane

determination method

2 references

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

phagocytic vesicle

determination method

1 reference

14 February 2019

Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

external side of plasma membrane

determination method

4 references

14 February 2019

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

14 February 2019

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

biological process

natural killer cell differentiation

determination method

1 reference

14 February 2019

Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

adaptive immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

natural killer cell proliferation

determination method

1 reference

14 February 2019

Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

T-helper 1 cell cytokine production

determination method

1 reference

14 February 2019

Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

negative regulation of T cell cytokine production

determination method

1 reference

14 February 2019

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

regulation of vesicle fusion

determination method

1 reference

14 February 2019

Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

lymphocyte activation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

innate immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

regulation of catalytic activity

determination method

1 reference

14 February 2019

Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

positive regulation of activated T cell proliferation

determination method

1 reference

14 February 2019

Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

leukocyte chemotaxis involved in inflammatory response

determination method

1 reference

14 February 2019

Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

positive regulation of dendritic cell chemotaxis

determination method

1 reference

14 February 2019

Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

myeloid dendritic cell activation involved in immune response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

negative regulation of interleukin-12 production

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

negative regulation of interleukin-6 production

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

positive regulation of JNK cascade

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

negative regulation of CD40 signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUM4

determination method

signal transduction

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUM4&geneProductId=UniProtKB:Q9QUM4

determination method

Signaling lymphocytic activation molecule, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUM4

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUM4

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000015460

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000015460

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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