SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Q21984492)

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mammalian protein found in Mus musculus
  • protein brahma homolog 1
  • Smarca4
  • SNF2-beta
  • ATP-dependent helicase SMARCA4
  • transcription activator BRG1
  • BRG1-associated factor 190A
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • BAF190A
edit
Language Label Description Also known as
English
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
mammalian protein found in Mus musculus
  • protein brahma homolog 1
  • Smarca4
  • SNF2-beta
  • ATP-dependent helicase SMARCA4
  • transcription activator BRG1
  • BRG1-associated factor 190A
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • BAF190A

Statements

part of
molecular function
protein binding
determination method
IPI
28 references
retrieved
9 May 2019
stated in
An essential switch in subunit composition of a chromatin remodeling complex during neural development
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Identification of a polymorphic, neuron-specific chromatin remodeling complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Expression of the Wdr9 gene and protein products during mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Chromatin regulation by Brg1 underlies heart muscle development and disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Telomerase modulates Wnt signalling by association with target gene chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal fusion transcripts in a girl with intellectual disability and neuropsychiatric alterations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
BAF complexes facilitate decatenation of DNA by topoisomerase IIα
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
retrieved
9 May 2019
stated in
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IPI
chromatin binding
determination method
IDA
ISO
7 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
ISO
retrieved
9 May 2019
stated in
MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
cell component
nucleus
determination method
IDA
IEA
ISO
12 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IEA
retrieved
14 February 2019
stated in
SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
14 February 2019
stated in
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
13 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IEA
retrieved
9 May 2019
stated in
Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IMP
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
ISO
retrieved
14 February 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IMP
retrieved
14 February 2019
stated in
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IMP
retrieved
14 February 2019
stated in
The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IGI
retrieved
14 February 2019
stated in
SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IGI
IMP
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
ISO
retrieved
9 May 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IMP
retrieved
9 May 2019
stated in
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IMP
retrieved
9 May 2019
stated in
The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IGI
retrieved
9 May 2019
stated in
SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q3TKT4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TKT4
determination method
IBA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21984492&oldid=2023240188"