Hairy/enhancer-of-split related with YRPW motif 2 (Q21985972)

http://www.ebi.ac.uk/interpro/protein/Q9QUS4

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

microsatellite binding

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

3 references

9 May 2019

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

sequence-specific DNA binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

protein dimerization activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

protein homodimerization activity

1 reference

9 May 2019

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

DNA-binding transcription factor activity

4 references

9 May 2019

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

transcription factor binding

1 reference

9 May 2019

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

RNA polymerase II general transcription initiation factor activity

IPI

1 reference

10 September 2018

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

4 references

9 May 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

protein heterodimerization activity

IPI

1 reference

9 May 2019

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

transcription corepressor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

microsatellite binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

14 February 2019

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

transcription regulator complex

1 reference

9 May 2019

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

dorsal aorta morphogenesis

biological process

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac vascular smooth muscle cell development

1 reference

9 May 2019

Transcription factor CHF1/Hey2 regulates coronary vascular maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

pulmonary valve morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of inner ear auditory receptor cell differentiation

1 reference

9 May 2019

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

heart trabecula formation

1 reference

9 May 2019

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

tricuspid valve morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of vasculogenesis

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

pulmonary artery morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac septum morphogenesis

1 reference

9 May 2019

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

muscular septum morphogenesis

ISS

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

ventricular septum morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

protein-DNA complex assembly

cardiac muscle hypertrophy

1 reference

9 May 2019

The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

outflow tract morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

ascending aorta morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac left ventricle morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

labyrinthine layer blood vessel development

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

coronary vasculature morphogenesis

1 reference

9 May 2019

Transcription factor CHF1/Hey2 regulates coronary vascular maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of gene expression

3 references

9 May 2019

The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

endocardial cushion to mesenchymal transition involved in heart valve formation

1 reference

9 May 2019

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

ventricular trabecula myocardium morphogenesis

1 reference

9 May 2019

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

positive regulation of heart rate

1 reference

9 May 2019

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

atrial septum morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of cardiac muscle cell apoptotic process

1 reference

9 May 2019

The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

arterial endothelial cell differentiation

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

blood vessel development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

positive regulation of cardiac muscle cell proliferation

1 reference

9 May 2019

CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac muscle hypertrophy in response to stress

1 reference

9 May 2019

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

umbilical cord morphogenesis

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of transcription regulatory region DNA binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

mesenchymal cell development

1 reference

9 May 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of gene expression

1 reference

9 May 2019

Transcription factor CHF1/Hey2 regulates coronary vascular maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

vascular associated smooth muscle cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

anterior/posterior axis specification

1 reference

9 May 2019

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

tricuspid valve formation

1 reference

9 May 2019

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of transcription, DNA-templated

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac ventricle morphogenesis

1 reference

9 May 2019

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

atrioventricular valve development

1 reference

9 May 2019

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

cardiac right ventricle morphogenesis

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

ventricular cardiac muscle cell development

1 reference

9 May 2019

CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of Notch signaling pathway

cardiac epithelial to mesenchymal transition

2 references

1 reference

9 May 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

Notch signaling involved in heart development

1 reference

9 May 2019

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

IC

Notch signaling pathway

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

16 July 2018

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QUS4&geneProductId=UniProtKB:Q9QUS4

Notch signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

regulation of neurogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

positive regulation of gene expression

1 reference

9 May 2019

Inhibitory role of Notch1 in calcific aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of biomineral tissue development

1 reference

9 May 2019

Inhibitory role of Notch1 in calcific aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

negative regulation of transcription by RNA polymerase II

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

circulatory system development

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUS4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUS4

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

stated in

InterPro Release 71.0