Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti (Q28507372)

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20 January 2020

title

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti (English)

2 references

24 January 2017

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20 January 2020

1 reference

Hairy/enhancer-of-split related with YRPW motif 2

1 reference

Atonal bHLH transcription factor 1

1 reference

Recombination signal binding protein for immunoglobulin kappa J region

1 reference

0 references

4

1 reference

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20 January 2020

Andrew K. Groves

5

1 reference

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20 January 2020

author name string

Angelika Doetzlhofer

1

2 references

24 January 2017

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20 January 2020

Takahiro Ohyama

3

2 references

24 January 2017

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20 January 2020

Neil Segil

6

2 references

24 January 2017

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20 January 2020

Martin L Basch

2

1 reference

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20 January 2020

language of work or name

English

0 references

publication date

1 January 2009

2 references

24 January 2017

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20 January 2020

number of pages

12

1 reference

inferred from page(s)

2 references

24 January 2017

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20 January 2020

volume

16

2 references

24 January 2017

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20 January 2020

page(s)

58-69

1 reference

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20 January 2020

issue

1

2 references

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describes a project that uses

20 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2696015/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development

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Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment

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Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti

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Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling

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gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

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Fibroblast growth factor signaling regulates pillar cell development in the organ of corti

19 March 2017

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

19 March 2017

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Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

19 March 2017

1 reference

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Hes1 is a negative regulator of inner ear hair cell differentiation

19 March 2017

1 reference

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Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

19 March 2017

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Math1: an essential gene for the generation of inner ear hair cells

19 March 2017

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19 March 2017

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Notch signalling pathway mediates hair cell development in mammalian cochlea

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19 March 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.

29 September 2017

1 reference

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.

29 September 2017

1 reference

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Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation.

29 September 2017

1 reference

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From placode to polarization: new tunes in inner ear development

29 September 2017

1 reference

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Math1-driven GFP expression in the developing nervous system of transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

A portrait of Alzheimer secretases--new features and familiar faces

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Notch signaling in the development of the inner ear: lessons from Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Detection of multiple gene products simultaneously by in situ hybridization and immunohistochemistry in whole mounts of avian embryos

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Gamma-secretase: proteasome of the membrane?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696015

A garden of Notch-ly delights

27 November 2018

1 reference

12 December 2020

Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear

1 reference

12 December 2020

Multiple roles of Notch signaling in cochlear development

1 reference

12 December 2020

Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

1 reference

12 December 2020

Morphology of the monotreme organ of Corti and macula lagena

1 reference

12 December 2020

10.1016/J.DEVCEL.2008.11.008

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19154718%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

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20 January 2020

2 references