Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells (Q22008790)

protein autophosphorylation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Y Shi

1

Y

Shi

1 reference

7 February 2023

J An

2

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J Liang

3

J

Liang

1 reference

7 February 2023

S E Hayes

4

S E

Hayes

1 reference

7 February 2023

G E Sandusky

5

G E

Sandusky

1 reference

7 February 2023

L E Stramm

6

L E

Stramm

1 reference

7 February 2023

N N Yang

7

N N

Yang

1 reference

Journal of Biological Chemistry

7 February 2023

language of work or name

English

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publication date

26 February 1999

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published in

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volume

274

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issue

9

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page(s)

5723-30

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cites work

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Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells

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Control of insulin gene expression by glucose

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Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

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Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

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Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

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Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

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Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

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The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation

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Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase

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Molecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum

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Erythroid expression of the heme-regulated eIF-2 alpha kinase

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Viroid-induced phosphorylation of a host protein related to a dsRNA-dependent protein kinase.

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

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Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog

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Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

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Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

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Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

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Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins

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Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.

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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents

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Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans

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Mutations in the Double-stranded RNA-activated Protein Kinase Insert Region That Uncouple Catalysis from eIF2α Binding

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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

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Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

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Identifiers

DOI

10.1074/JBC.274.9.5723

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