Vaccination Strategies for Alzheimer???s Disease (Q22241439)

Dimensions

6 February 2023

Tracey C Dickson

2

Tracey C.

Dickson

1 reference

Dimensions

6 February 2023

James C Vickers

3

James C.

Vickers

1 reference

Dimensions

1037530402

https://scigraph.springernature.com/pub.10.2165/00002512-200724020-00003

6 February 2023

language of work or name

English

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publication date

2007

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1 reference

24

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issue

2

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page(s)

107-119

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107-19

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exact match

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cites work

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

The neurobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Transgenic mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00002512-200724020-00003

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

12 December 2020

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

1 reference

12 December 2020

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

12 December 2020

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

12 December 2020

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

1 reference

12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

12 December 2020

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease

1 reference

12 December 2020

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor.

1 reference

12 December 2020

Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

1 reference

12 December 2020

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice

1 reference

12 December 2020

Dosing in phase II trial of Alzheimer's vaccine suspended

1 reference

12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

12 December 2020

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

1 reference

12 December 2020

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

The cause of neuronal degeneration in Alzheimer's disease

1 reference

12 December 2020

Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model mice.

1 reference

12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

12 December 2020

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

12 December 2020

An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease.

1 reference

12 December 2020

Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety

1 reference

12 December 2020

alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury

1 reference

12 December 2020

Evidence that transmitter-containing dystrophic neurites precede paired helical filament and Alz-50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease.

1 reference

12 December 2020

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

1 reference

12 December 2020

Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody

1 reference

12 December 2020

Immunization of Alzheimer model mice with adenovirus vectors encoding amyloid beta-protein and GM-CSF reduces amyloid load in the brain

1 reference

12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

12 December 2020

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

12 December 2020

Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.

1 reference

12 December 2020

Nerve inflammation halts trial for Alzheimer's drug.

1 reference

12 December 2020

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

1 reference

12 December 2020

Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets

1 reference

12 December 2020

Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

12 December 2020

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

1 reference

12 December 2020

Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies

1 reference

12 December 2020

A grading system of Alzheimer disease lesions in neocortical areas

1 reference

12 December 2020

Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Specific humoral immune responses in rhesus monkeys vaccinated with the Alzheimer's disease-associated beta-amyloid 1-15 peptide vaccine.

1 reference

12 December 2020

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

1 reference

12 December 2020

Neuropathological stageing of Alzheimer-related changes

1 reference

12 December 2020

Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis.

1 reference

12 December 2020

Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice

1 reference

12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

1 reference

12 December 2020

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

12 December 2020

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

12 December 2020

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

12 December 2020

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

12 December 2020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

12 December 2020

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

12 December 2020

Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies.

1 reference

12 December 2020

The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol

1 reference

12 December 2020

Alzheimer's disease. The ins and outs of amyloid-beta

1 reference

12 December 2020

Transgenic mouse models of Alzheimer's disease: phenotype and application

1 reference

12 December 2020

Dystrophic neurite formation associated with age-related beta amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology.

1 reference

12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

12 December 2020

A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Effects of epitopes combination and adjuvants on immune responses to anti-Alzheimer disease DNA vaccines in mice

1 reference

12 December 2020

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

1 reference

12 December 2020

Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

1 reference

12 December 2020

Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain

1 reference

12 December 2020

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging.

1 reference

12 December 2020

Development of a novel diffusion-based method to estimate the size of the aggregated Abeta species responsible for neurotoxicity

1 reference

12 December 2020

Cognitive enhancement therapy for Alzheimer's disease. The way forward

1 reference

12 December 2020

Virosome-based active immunization targets soluble amyloid species rather than plaques in a transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease.

1 reference

12 December 2020

Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

1 reference

12 December 2020

Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576.

1 reference

12 December 2020

Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease.

1 reference

12 December 2020

Active immunization of mice with an Abeta-Hsp70 vaccine.

1 reference

12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

12 December 2020

Abeta associated neuropil changes: correlation with neuronal loss and dementia

1 reference

12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

12 December 2020

Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

1 reference

12 December 2020

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

12 December 2020

Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis

1 reference

12 December 2020

Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum.

1 reference

12 December 2020

Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease

1 reference

12 December 2020

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

1 reference

12 December 2020

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

1 reference

12 December 2020

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

12 December 2020

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

1 reference

12 December 2020

Neuropil threads occur in dendrites of tangle-bearing nerve cells

1 reference

12 December 2020

Efficacy of anti-Abeta antibody isotypes used for intracerebroventricular immunization in TgCRND8.

1 reference

12 December 2020

Molecular pathways to neurodegeneration

1 reference

12 December 2020

Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice

1 reference

12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

12 December 2020

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

1 reference

12 December 2020

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway

1 reference

12 December 2020

Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments

1 reference

12 December 2020

HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses.

1 reference

12 December 2020

Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.

1 reference

12 December 2020

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

12 December 2020

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

1 reference

12 December 2020

Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration.

1 reference

12 December 2020

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.

1 reference

12 December 2020

Pharmacological treatment of cognitive deficits in Alzheimer's disease.

1 reference

12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

12 December 2020

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Neprilysin regulates amyloid Beta peptide levels

1 reference

12 December 2020

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

1 reference

12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

12 December 2020

10.2165/00002512-200724020-00003

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DOI

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