Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS (Q22242658)

Europe PubMed Central

title

Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS (English)

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J. B. Alimonti

1

Judie B

Alimonti

1 reference

PubMed

PubMed publication ID

12810858

8 February 2023

T Blake Ball

author given names

T Blake

author last names

Ball

series ordinal

2

1 reference

PubMed

PubMed publication ID

12810858

8 February 2023

Keith R Fowke

author given names

Keith R

author last names

Fowke

series ordinal

3

1 reference

PubMed

PubMed publication ID

12810858

Journal of General Virology

8 February 2023

language of work or name

English

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publication date

1 July 2003

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published in

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volume

84

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issue

7

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page(s)

1649-1661

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cites work

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7 January 2021

Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy

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7 January 2021

IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2.

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7 January 2021

High levels of HIV-1 replication show a clear correlation with downmodulation of Bcl-2 protein in peripheral blood lymphocytes of HIV-1-seropositive subjects

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7 January 2021

Effects of the exogenous Nef protein on HIV-1 target cells

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7 January 2021

CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients

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7 January 2021

Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?

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7 January 2021

HIV-1 Tat protects CD4+ Jurkat T lymphoblastoid cells from apoptosis mediated by TNF-related apoptosis-inducing ligand.

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7 January 2021

Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells.

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7 January 2021

Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization

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7 January 2021

The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells

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7 January 2021

Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like Events

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7 January 2021

A cellular anti-apoptosis protein is cleaved by the HIV-1 protease

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7 January 2021

Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression

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7 January 2021

High plasma level of soluble tumor necrosis factor receptor type II (sTNFRII) in asymptomatic HIV-1-infected patients

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7 January 2021

Tumor-specific targeting of T helper type 1 (Th1) cells by anti-CD3 x anti-c-ErbB-2 bispecific antibody

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers

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7 January 2021

HIV-1 Nef binding protein expressed on the surface of murine blood cells

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7 January 2021

Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The Th1-Th2 hypothesis of HIV infection: new insights

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Fas and Fas ligand: lpr and gld mutations

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Recombinant nef HIV-IIIB protein is toxic to human neurons in culture

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas).

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The machinery of programmed cell death.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Ligation of human CD4 interferes with antigen-induced activation of primary T cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Influence of mitochondrial control of apoptosis on the pathogenesis, complications and treatment of HIV infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Apoptosis: an innate immune response to virus infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Viral dynamics in human immunodeficiency virus type 1 infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Inhibition of death receptor signals by cellular FLIP

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression.

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

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https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Regulation of T-helper cell responses to inhalant allergen during early childhood

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Effects of interferon-alpha on gene expression of chemokines and members of the tumour necrosis factor superfamily in HIV-infected patients

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Synergistic stimulatory effects of tumour necrosis factor alpha and interferon gamma on replication of human immunodeficiency virus type 1 and on apoptosis of HIV-1-infected host cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Nef protein induces differential effects in CD8+ cells from HIV-1-infected patients

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Regulation of T-cell apoptosis: a mixed lymphocyte reaction model

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1-specific cellular immune responses among HIV-1-resistant sex workers

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

A two-step, two-signal model for the primary activation of precursor helper T cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Suicidal tendencies: apoptotic cell death by caspase family proteinases

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

BCL-2 proteins: regulators of the mitochondrial apoptotic program

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Caspase activation is required for T cell proliferation

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Inhibition of immunoreactive tumor necrosis factor-alpha by a chimeric antibody in patients infected with human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Antigen-stimulated apoptotic T-cell death in HIV infection is selective for CD4+ T cells, modulated by cytokines and effected by lymphotoxin.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Immunologic and virologic evaluation after influenza vaccination of HIV-1-infected patients

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CCR5 mediates Fas- and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Cell death in us and others

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

A matter of life and cell death

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

The human immunodeficiency virus: infectivity and mechanisms of pathogenesis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

1 reference

7 January 2021

Repression of MHC class I gene promoter activity by two-exon Tat of HIV

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

1 reference

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Clinical significance of cytomegalovirus-specific T helper responses and cytokine production in lung transplant recipients

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Role of bcl-2 and apoptosis in viral infections

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

In vivo analysis of Fas/FasL interactions in HIV-infected patients.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Murine leishmaniosis: a paradigm for the importance of T helper 1 and T helper 2 cells.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Host determinants in HIV infection and disease. Part 2: genetic factors and implications for antiretroviral therapeutics

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021

Host determinants in HIV infection and disease. Part 1: cellular and humoral immune responses

1 reference

https://api.crossref.org/works/10.1099%2FVIR.0.19110-0

7 January 2021