Plasma membrane monoamine transporters: structure, regulation and function (Q22251021)

Europe PubMed Central

title

Plasma membrane monoamine transporters: structure, regulation and function (English)

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Gonzalo E. Torres

1

Gonzalo E.

Torres

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Dimensions

7 February 2023

Raul R. Gainetdinov

series ordinal

2

author given names

Raul R.

author last names

Gainetdinov

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Dimensions

7 February 2023

Marc G. Caron

series ordinal

3

author given names

Marc G.

author last names

Caron

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Dimensions

Nature Reviews Neuroscience

7 February 2023

language of work or name

English

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publication date

January 2003

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published in

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volume

4

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page(s)

13-25

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issue

1

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cites work

Fate of tritiated noradrenaline at the sympathetic nerve-endings

1 reference

Role of transmitter uptake mechanisms in synaptic neurotransmission

31 March 2020

1 reference

Neurotransmitter transporters as molecular targets for addictive drugs.

31 March 2020

1 reference

Dopamine transporters and neuronal injury

31 March 2020

1 reference

Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals

31 March 2020

1 reference

Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines

31 March 2020

1 reference

Cocaine receptors on dopamine transporters are related to self-administration of cocaine

31 March 2020

1 reference

Amphetamine: effects on catecholamine systems and behavior

31 March 2020

1 reference

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

31 March 2020

1 reference

Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter

31 March 2020

1 reference

Neurobiology of addiction

31 March 2020

1 reference

The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

31 March 2020

1 reference

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

31 March 2020

1 reference

Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.

31 March 2020

1 reference

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

31 March 2020

1 reference

Cloning and expression of a rat brain GABA transporter

31 March 2020

1 reference

Cloning and expression of a cocaine-sensitive rat dopamine transporter

31 March 2020

1 reference

Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

31 March 2020

1 reference

Cloning of the cocaine-sensitive bovine dopamine transporter

31 March 2020

1 reference

Cloning and functional characterization of a cocaine-sensitive dopamine transporter

31 March 2020

1 reference

Cloning and expression of a functional serotonin transporter from rat brain

31 March 2020

1 reference

Cloning of a serotonin transporter affected by antidepressants

31 March 2020

1 reference

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

31 March 2020

1 reference

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

31 March 2020

1 reference

Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter

31 March 2020

1 reference

A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization

31 March 2020

1 reference

Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster

31 March 2020

1 reference

Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter

31 March 2020

1 reference

Molecular cloning and organization of the coding region of the human norepinephrine transporter gene

31 March 2020

1 reference

Cloning and expression of the mouse serotonin transporter

31 March 2020

1 reference

The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression

31 March 2020

1 reference

Cloning and chromosomal mapping of the murine norepinephrine transporter.

31 March 2020

1 reference

Molecular cloning, expression and characterization of a bovine serotonin transporter.

31 March 2020

1 reference

The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.

31 March 2020

1 reference

Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.

31 March 2020

1 reference

A cocaine insensitive chimeric insect serotonin transporter reveals domains critical for cocaine interaction

31 March 2020

1 reference

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR.

31 March 2020

1 reference

The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

31 March 2020

1 reference

Structure and organization of the gene encoding human dopamine transporter.

31 March 2020

1 reference

Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16

31 March 2020

1 reference

Functional characterization of the splicing variants of human norepinephrine transporter

31 March 2020

1 reference

Characterization of the 5'-flanking region of the human dopamine transporter gene

31 March 2020

1 reference

Cloning and functional characterization of the human norepinephrine transporter gene promoter

31 March 2020

1 reference

Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene

31 March 2020

1 reference

A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene.

31 March 2020

1 reference

Antipeptide antibodies confirm the topology of the human norepinephrine transporter

31 March 2020

1 reference

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

31 March 2020

1 reference

Accessibility and conformational coupling in serotonin transporter predicted internal domains.

31 March 2020

1 reference

Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium

31 March 2020

1 reference

The region of dopamine transporter encompassing the 3rd transmembrane domain is crucial for function

31 March 2020

1 reference

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

31 March 2020

1 reference

Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

31 March 2020

1 reference

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

31 March 2020

1 reference

Delineation of an endogenous zinc-binding site in the human dopamine transporter

31 March 2020

1 reference

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

31 March 2020

1 reference

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

31 March 2020

1 reference

The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis

31 March 2020

1 reference

Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition.

31 March 2020

1 reference

Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains.

31 March 2020

1 reference

Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine.

31 March 2020

1 reference

High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol.

31 March 2020

1 reference

The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

31 March 2020

1 reference

Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants

31 March 2020

1 reference

The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

31 March 2020

1 reference

Permeation and gating residues in serotonin transporter

31 March 2020

1 reference

A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter

31 March 2020

1 reference

An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism

31 March 2020

1 reference

Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents

31 March 2020

1 reference

A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter

31 March 2020

1 reference

From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters

31 March 2020

1 reference

Conducting states of a mammalian serotonin transporter.

31 March 2020

1 reference

Norepinephrine transporters have channel modes of conduction

31 March 2020

1 reference

Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

31 March 2020

1 reference

Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons.

31 March 2020

1 reference

The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation.

31 March 2020

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The membrane-bound rat serotonin transporter, SERT1, is an oligomeric protein

31 March 2020

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Possible existence of quaternary structure in the high-affinity serotonin transport complex.

31 March 2020

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Oligomerization of serotonin transporter and its functional consequences

31 March 2020

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Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

31 March 2020

1 reference

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

31 March 2020

1 reference

Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

31 March 2020

1 reference

Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes

31 March 2020

1 reference

Regulation of the functional activity of the human dopamine transporter by protein kinase C.

31 March 2020

1 reference

Role of protein kinase C and second messengers in regulation of the norepinephrine transporter

31 March 2020

1 reference

Phosphorylation and regulation of antidepressant-sensitive serotonin transporters

31 March 2020

1 reference

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

31 March 2020

1 reference

Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters

31 March 2020

1 reference

Membrane trafficking regulates the activity of the human dopamine transporter

31 March 2020

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Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

31 March 2020

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Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

31 March 2020

1 reference

Cocaine increases dopamine uptake and cell surface expression of dopamine transporters

31 March 2020

1 reference

Cocaine induction of dopamine transporter trafficking to the plasma membrane

31 March 2020

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Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein

31 March 2020

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Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases.

31 March 2020

1 reference

Dopamine transporters are phosphorylated on N-terminal serines in rat striatum

31 March 2020

1 reference

Chronic and acute regulation of Na+/Cl- -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems

31 March 2020

1 reference

Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors

31 March 2020

1 reference

Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level

31 March 2020

1 reference

Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter.

31 March 2020

1 reference

Dopamine transporters in the nucleus accumbens and the striatum have different apparent molecular weights.

31 March 2020

1 reference

Species differences in dopamine transporters: postmortem changes and glycosylation differences.

31 March 2020

1 reference

Developmentally regulated glycosylation of dopamine transporter.

31 March 2020

1 reference

N-linked oligosaccharides are required for cell surface expression of the norepinephrine transporter but do not influence substrate or inhibitor recognition.

31 March 2020

1 reference

Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.

31 March 2020

1 reference

Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C.

31 March 2020

1 reference

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

31 March 2020

1 reference

31 March 2020

Genetics of parkinsonism

1 reference

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

31 March 2020

1 reference

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

31 March 2020

1 reference

The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter

31 March 2020

1 reference

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

31 March 2020

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Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

31 March 2020

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Profound neuronal plasticity in response to inactivation of the dopamine transporter

31 March 2020

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Monoamine transporter pharmacology and mutant mice

31 March 2020

1 reference

Monoamine transporters: from genes to behavior

31 March 2020

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Altered expression and functions of serotonin 5-HT1Aand 5-HT1Breceptors in knock-out mice lacking the 5-HT transporter

31 March 2020

1 reference

Cocaine self-administration in dopamine-transporter knockout mice

31 March 2020

1 reference

Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

31 March 2020

1 reference

Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

31 March 2020

1 reference

Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene.

31 March 2020

1 reference

Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice.

31 March 2020

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Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.

31 March 2020

1 reference

Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity

31 March 2020

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PET studies of brain monoamine transporters.

31 March 2020

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Decreased dopamine transporters with age in health human subjects.

31 March 2020

1 reference

Dopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease

31 March 2020

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Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo

31 March 2020

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[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

31 March 2020

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Striatal dopamine transporter density in major depression

31 March 2020

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Dopamine transporter density in patients with attention deficit hyperactivity disorder.

31 March 2020

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Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour.

31 March 2020

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Reduced central serotonin transporters in alcoholism.

31 March 2020

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Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography.

31 March 2020

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Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.

31 March 2020

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

31 March 2020

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Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.

31 March 2020

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Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders

31 March 2020

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Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

31 March 2020

1 reference

Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system.

31 March 2020

1 reference

Dopamine transporter immunoreactivity in rat brain

31 March 2020

1 reference

The dopamine transporter: immunochemical characterization and localization in brain

31 March 2020

1 reference

Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter

31 March 2020

1 reference

Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies.

31 March 2020

1 reference

Immunocytochemical detection of the serotonin transporter in rat brain

31 March 2020

1 reference

The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

31 March 2020

1 reference

Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence.

31 March 2020

1 reference

The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines

31 March 2020

1 reference

Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland

31 March 2020

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High-affinity uptake of serotonin into immunocytochemically identified astrocytes.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN1008

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Consolidated OpenCitations Corpus – April 2017

128060

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128060

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference