A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging (Q22337238)

Óscar Fernández-Capetillo

7 February 2023

object named as

Oscar Fernandez-Capetillo

10

Oscar

Fernandez-Capetillo

1 reference

7 February 2023

4

Rebeca Soria

Rebeca

Soria

1 reference

7 February 2023

1

Matilde Murga

Matilde

Murga

1 reference

7 February 2023

Samuel Bunting

2

Samuel

Bunting

1 reference

7 February 2023

Maria F Montaña

3

Maria F

Montaña

1 reference

7 February 2023

Marta Cañamero

6

Marta

Cañamero

1 reference

7 February 2023

Youngsoo Lee

7

Youngsoo

Lee

1 reference

7 February 2023

Peter J McKinnon

8

Peter J

McKinnon

1 reference

7 February 2023

Andre Nussenzweig

9

Andre

Nussenzweig

1 reference

Two faces of p53: aging and tumor suppression

7 February 2023

language of work or name

English

0 references

publication date

August 2009

0 references

published in

Nature Genetics

0 references

volume

41

0 references

issue

8

0 references

page(s)

891-8

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Chromosomal instability at common fragile sites in Seckel syndrome

19 March 2017

1 reference

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

WAF1, a potential mediator of p53 tumor suppression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

The DNA damage response: ten years after

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

19 March 2017

1 reference

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

ATR Regulates Fragile Site Stability

19 March 2017

1 reference

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https://api.crossref.org/works/10.1038/NG.420

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

22 April 2017

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Atm-deficient mice: a paradigm of ataxia telangiectasia

22 April 2017

1 reference

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Tumor spectrum analysis in p53-mutant mice

7 April 2017

1 reference

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

7 April 2017

1 reference

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Stems cells and the pathways to aging and cancer

27 September 2017

1 reference

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The placenta and intrauterine programming.

27 September 2017

1 reference

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Age to survive: DNA damage and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Global chromatin compaction limits the strength of the DNA damage response

27 September 2017

1 reference

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Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome

27 September 2017

1 reference

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Mechanisms of disease: is osteoporosis the obesity of bone?

27 September 2017

1 reference

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Intrauterine programming of physiological systems: causes and consequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Associated hormonal decline in aging: is there a role for GH therapy in aging men?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

DNA repair, genome stability, and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Nbs1 is required for ATR-dependent phosphorylation events

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1-q24.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Central nervous system anomalies in Seckel syndrome: report of a new family and review of the literature

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Do some patients with Seckel syndrome have hematological problems and/or chromosome breakage?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Age-associated characteristics of murine hematopoietic stem cells

27 September 2017

1 reference

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Seckel-like syndrome in three siblings

30 May 2018

1 reference

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The aging of hematopoietic stem cells

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Seckel syndrome in a family with three affected children and hematological manifestations associated with chromosome instability.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Effects of prenatal irradiation on the development of cerebral cortex and corpus callosum of the mouse.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Pigmentary changes in Seckel’s syndrome

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

30 May 2018

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Delayed ageing through damage protection by the Arf/p53 pathway

29 November 2018

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Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Dual roles of ATM in the cellular response to radiation and in cell growth control.

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance.

29 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2902278

The Wellcome Foundation Lecture, 1994. The fetal origins of adult disease

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19620979

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.420

1 reference

860455

0 references

860455

1 reference

1 reference

1 reference