Protein phosphatase 2 catalytic subunit alpha (Q21114999)

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mammalian protein found in Homo sapiens
  • protein phosphatase 2, catalytic subunit, alpha isozyme
  • serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
  • replication protein C
  • RP-C
  • PPP2CA
  • serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  • PP2A-alpha
  • protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
edit
Language Label Description Also known as
English
Protein phosphatase 2 catalytic subunit alpha
mammalian protein found in Homo sapiens
  • protein phosphatase 2, catalytic subunit, alpha isozyme
  • serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
  • replication protein C
  • RP-C
  • PPP2CA
  • serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  • PP2A-alpha
  • protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Statements

molecular function
protein binding
determination method
IPI
52 references
retrieved
8 April 2019
stated in
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
FAM122A, a new endogenous inhibitor of protein phosphatase 2A
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments
GOA
curator
UniProt
UniProt protein ID
P67775
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Physical association of GPR54 C-terminal with protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor PP2A Abeta regulates the RalA GTPase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
An integrated workflow for charting the human interaction proteome: insights into the PP2A system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2A interacts with and directly dephosphorylates RelA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
STRIPAK components determine mode of cancer cell migration and metastasis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Shugoshin collaborates with protein phosphatase 2A to protect cohesin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of nucleoredoxin with protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a new family of protein phosphatase 2A regulatory subunits
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Alpha 4 associates with protein phosphatases 2A, 4, and 6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Heterochromatin links to centromeric protection by recruiting shugoshin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P67775
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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