Regulation of p53 activity in nuclear bodies by a specific PML isoform (Q24290520)

GOA release 2020-03-11

author name string

V Fogal

1

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M Gostissa

2

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P Sandy

3

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P Zacchi

4

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T Sternsdorf

5

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K Jensen

6

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P P Pandolfi

7

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H Will

8

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C Schneider

9

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G Del Sal

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

10

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language of work or name

English

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publication date

15 November 2000

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published in

The EMBO Journal

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volume

19

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issue

22

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page(s)

6185-95

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cites work

1 reference

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19 March 2017

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SUMO-1 modification activates the transcriptional response of p53

19 March 2017

1 reference

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

19 March 2017

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

19 March 2017

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Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

19 March 2017

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The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

19 March 2017

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Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

19 March 2017

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Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1

19 March 2017

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A model for p53-induced apoptosis

19 March 2017

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

19 March 2017

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p53, the cellular gatekeeper for growth and division

19 March 2017

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WAF1, a potential mediator of p53 tumor suppression

19 March 2017

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Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres

19 March 2017

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19 March 2017

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

19 March 2017

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The transcriptional role of PML and the nuclear body

19 March 2017

1 reference

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PML is essential for multiple apoptotic pathways

19 March 2017

1 reference

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The complexity of p53 modulation: emerging patterns from divergent signals

19 March 2017

1 reference

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Identification of three major sentrinization sites in PML

19 March 2017

1 reference

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Recruitment of p300/CBP in p53-dependent signal pathways

19 March 2017

1 reference

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

19 March 2017

1 reference

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The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Role of PML in cell growth and the retinoic acid pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

The growth arrest-specific gene, gas1, is involved in growth suppression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

The p66shc adaptor protein controls oxidative stress response and life span in mammals

19 March 2017

1 reference

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7 April 2017

p53: puzzle and paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

7 April 2017

1 reference

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PML is induced by oncogenic ras and promotes premature senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

p53 is involved in the p120E4F-mediated growth arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

The cellular response to p53: the decision between life and death

27 September 2017

1 reference

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Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.

27 September 2017

1 reference

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The PML nuclear bodies: actors or extras?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Molecular genetics of acute promyelocytic leukemia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

PML induces a novel caspase-independent death process

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Nuclear domain 10, the site of DNA virus transcription and replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

The acute promyelocytic leukaemia-associated PML gene is induced by interferon.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305840

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11080164

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/19.22.6185

1 reference

172511

172511

1 reference

1 reference

1 reference