The cellular response to p53: the decision between life and death (Q33771774)

29 July 2017

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title

The cellular response to p53: the decision between life and death (English)

1 reference

29 July 2017

Sionov RV

1

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29 July 2017

Haupt Y

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

6145-6157

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29 July 2017

45

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203130

29 July 2017

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cites work

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The role of p53 in tumour suppression: lessons from mouse models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Thyroid hormone receptor is a negative regulator in p53-mediated signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mechanisms of p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Bcl-2 inhibits p53 nuclear import following DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Loss of function and p53 protein stabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 represses ribosomal gene transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 is a general repressor of RNA polymerase III transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Bcl-2 blocks p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mechanisms of p53-induced apoptosis: in search of genes which are regulated during p53-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The in vitro phosphorylation of p53 by calcium-dependent protein kinase C--characterization of a protein-kinase-C-binding site on p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mechanisms of p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Signal transduction pathways that regulate cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

WT1--more than a transcription factor?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mdm2 association with p53 targets its ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The dual role model for p53 in maintaining genomic integrity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Identification of redox/repair protein Ref-1 as a potent activator of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Covalent and noncovalent modifiers of the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Reactive oxygen species are downstream mediators of p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Determination of cell fate by c-Abl activation in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Keeping an old friend under control: regulation of p53 stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Functional interplay between p53 and E2F through co-activator p300.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Protein kinase C isoform levels in normal and sodium dodecyl sulphate-irritated mouse skin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

1 reference

7 January 2021

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The BRCA2 gene product functionally interacts with p53 and RAD51

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Altered expression of the p53-regulated proteins, p21Waf1/Cip1, MDM2, and Bax in ultraviolet-irradiated human skin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Tumor suppressors. Teaming up to restrain cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Genetic determinants of p53-induced apoptosis and growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A model for p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Regulation of the mdm2 oncogene by thyroid hormone receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Essential role for p53-mediated transcription in E1A-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Effect of phosphorylation on tetramerization of the tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Ubiquitin, E6-AP, and their role in p53 inactivation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Regulation of CAK kinase activity by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Control of cell cycle progression by c-Jun is p53 dependent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Induction of Mdm2 and enhancement of cell survival by bFGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Discrimination of DNA binding sites by mutant p53 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Apoptosis by p53: mechanisms, regulation, and clinical implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Cell-cycle arrest versus cell death in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

GADD45 induction of a G2/M cell cycle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Role for p300 in stabilization of p53 in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203130

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203130

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference