Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1) (Q24291203)

Regulator of chromosome condensation 1

GOA release 2020-03-11

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protein heterodimerization activity

GOA release 2020-03-11

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GOA release 2020-03-11

guanine

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author name string

L Renault

1

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J Kuhlmann

2

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A Henkel

3

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A Wittinghofer

Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.

4

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language of work or name

English

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publication date

20 April 2001

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published in

Cell

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volume

105

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issue

2

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page(s)

245-55

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cites work

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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

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Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

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The structural basis of the activation of Ras by Sos

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The GTPase superfamily: a conserved switch for diverse cell functions

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The GTPase superfamily: conserved structure and molecular mechanism

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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

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Dissecting the interactions between NTF2, RanGDP, and the nucleoporin XFXFG repeats

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GEFs: structural basis for their activation of small GTP-binding proteins

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Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

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The glycine-rich loop of adenylate kinase forms a giant anion hole

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

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Structural Basis for Activation of ARF GTPase

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Transport between the cell nucleus and the cytoplasm

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A novel class of RanGTP binding proteins

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GTP hydrolysis by Ran is required for nuclear envelope assembly.

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7 January 2021

A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells

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7 January 2021

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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The ran GTPase regulates mitotic spindle assembly.

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The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution

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Functional expression in Escherichia coli of the mitotic regulator proteins p24ran and p45rcc1 and fluorescence measurements of their interaction

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7 January 2021

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

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7 January 2021

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

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7 January 2021

Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1

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7 January 2021

Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway

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Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

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Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization

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Electrostatic control of GTP and GDP binding in the oncoprotein p21ras

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Human RanBP3, a group of nuclear RanGTP binding proteins

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A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import

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[33] AMoRe: An automated molecular replacement program package

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Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein

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7 January 2021

Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran

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7 January 2021

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation

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Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates

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7 January 2021

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

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7 January 2021

The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller

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7 January 2021

Substrate and Product Structural Requirements for Binding of Nucleotides to H-ras p21: The Mechanism of Discrimination between Guanosine and Adenosine Nucleotides

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7 January 2021

NTF2 mediates nuclear import of Ran.

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7 January 2021

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

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7 January 2021

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

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7 January 2021

The P-loop--a common motif in ATP- and GTP-binding proteins

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Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

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GTPase-activating proteins: helping hands to complement an active site

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7 January 2021

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus

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7 January 2021

RCC1 in the Ran pathway

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7 January 2021

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects

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7 January 2021

Nuclear import of Ran is mediated by the transport factor NTF2.

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7 January 2021

Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFs

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7 January 2021

Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran

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7 January 2021

A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export

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7 January 2021

The ras protein family: evolutionary tree and role of conserved amino acids

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7 January 2021

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

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7 January 2021

Structural view of the Ran-Importin beta interaction at 2.3 A resolution

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7 January 2021

Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus

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7 January 2021

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

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7 January 2021

Ras signalling. Caught in the act of the switch-on

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7 January 2021

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

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7 January 2021

Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI).

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7 January 2021

A giant nucleopore protein that binds Ran/TC4

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7 January 2021

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

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7 January 2021

Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11336674

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Consolidated OpenCitations Corpus – April 2017