SIRT1 regulates UV-induced DNA repair through deacetylating XPA (Q24293574)

UV-damage excision repair

GOA release 2020-03-11

1 reference

Domains in the XPA protein important in its role as a processivity factor

GOA release 2020-03-11

author name string

Wei Fan

series ordinal

1

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Jianyuan Luo

series ordinal

2

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language of work or name

English

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publication date

30 July 2010

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published in

Molecular Cell

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volume

39

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issue

2

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page(s)

247-58

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cites work

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The eukaryotic nucleotide excision repair pathway

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

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Negative control of p53 by Sir2alpha promotes cell survival under stress

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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Mammalian SIRT1 represses forkhead transcription factors

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DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

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Quantitation and visualization of ultraviolet-induced DNA damage using specific antibodies: application to pigment cell biology

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SIRT1 promotes DNA repair activity and deacetylation of Ku70

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DBC1 is a negative regulator of SIRT1

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Negative regulation of the deacetylase SIRT1 by DBC1

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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

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How does SIRT1 affect metabolism, senescence and cancer?

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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

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Human xeroderma pigmentosum group A protein interacts with human replication protein A and inhibits DNA replication

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Acetylation of MyoD by p300 requires more than its histone acetyltransferase domain

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Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

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Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

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Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

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RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA)

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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

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Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation

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A functional link between SIRT1 deacetylase and NBS1 in DNA damage response

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