Negative control of p53 by Sir2alpha promotes cell survival under stress (Q24291828)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902177

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902176

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

Gene Ontology release 2020-05-02

1 reference

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

Sirtuin 1

1 reference

Transformation related protein 53

1 reference

author name string

J Luo

1

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A Y Nikolaev

2

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S Imai

3

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D Chen

4

0 references

F Su

5

0 references

A Shiloh

6

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L Guarente

7

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W Gu

Recruitment of p300/CBP in p53-dependent signal pathways

8

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language of work or name

English

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publication date

19 October 2001

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published in

Cell

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volume

107

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page(s)

137-48

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issue

2

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cites work

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts

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Oddball p53 in testicular tumors

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Impaired Fas response and autoimmunity in Pten+/- mice

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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Synergistic activation of transcription by CBP and p53

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A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

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The function of PML in p53-dependent apoptosis

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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Acetylation: a regulatory modification to rival phosphorylation?

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Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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p53, the cellular gatekeeper for growth and division

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Binding and modulation of p53 by p300/CBP coactivators

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

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A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

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7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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Atmospheric carbon dioxide concentrations over the past 60 million years

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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The Sir2 protein family: A novel deacetylase for gene silencing and more

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

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Acetylation of histones and transcription-related factors

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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Surfing the p53 network

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Involvement of p85 in p53-dependent apoptotic response to oxidative stress

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Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

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Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes

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7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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