The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt (Q24294452)

Tetratricopeptide repeat domain 3

GOA release 2020-03-11

1 reference

protein K48-linked ubiquitination

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

8

Takashi Kohno

0 references

Chikashi Obuse

11

object named as

Chikashi Obuse

0 references

Masayuki Noguchi

14

object named as

Masayuki Noguchi

0 references

author name string

Futoshi Suizu

1

0 references

Yosuke Hiramuki

2

0 references

Fumihiko Okumura

3

0 references

Mami Matsuda

4

0 references

Akiko J Okumura

5

0 references

Noriyuki Hirata

6

0 references

Masumi Narita

7

0 references

Jun Yokota

9

0 references

Miyuki Bohgaki

10

0 references

Shigetsugu Hatakeyama

12

0 references

Toshiyuki Obata

Mechanism of activation of protein kinase B by insulin and IGF-1

13

0 references

language of work or name

English

0 references

publication date

December 2009

0 references

published in

Developmental Cell

0 references

volume

17

0 references

page(s)

800-10

0 references

issue

6

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Ubiquitin: structures, functions, mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Differential activation of CREB by Akt1 and Akt2

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

The age of crosstalk: phosphorylation, ubiquitination, and beyond

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Too much of a good thing: mechanisms of gene action in Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Tetratrico peptide repeat interactions: to TPR or not to TPR?

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

The protooncogene TCL1 is an Akt kinase coactivator

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Evolution and function of ubiquitin-like protein-conjugation systems

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Chromosome 21 and down syndrome: from genomics to pathophysiology

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Regulation of the Akt kinase by interacting proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Akt and CHIP coregulate tau degradation through coordinated interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Proto-oncogene TCL1: more than just a coactivator for Akt

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Negative Regulation of AKT Activation by BRCA1

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.DEVCEL.2009.09.007

7 January 2021