Akt and CHIP coregulate tau degradation through coordinated interactions (Q24656202)

STIP1 homology and U-box containing protein 1

1 reference

Heat shock protein 90 alpha family class A member 1

1 reference

ubiquitin-dependent protein catabolic process

1 reference

Thymoma viral proto-oncogene 1

1 reference

STIP1 homology and U-Box containing protein 1

1 reference

author

Cam Patterson

10

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Leonard Petrucelli

16

object named as

Leonard Petrucelli

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author name string

Chad A Dickey

1

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John Koren

2

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Yong-Jie Zhang

3

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Ya-Fei Xu

4

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Umesh K Jinwal

5

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Morris J Birnbaum

6

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Bobby Monks

7

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Mei Sun

8

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Jin Q Cheng

9

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Rachel M Bailey

11

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Judith Dunmore

12

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Sareh Soresh

13

0 references

Carlos Leon

14

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Dave Morgan

Proceedings of the National Academy of Sciences of the United States of America

15

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language of work or name

English

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publication date

4 March 2008

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published in

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volume

105

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issue

9

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page(s)

3622-7

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cites work

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Current strategies for the treatment of Alzheimer's disease and other tauopathies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Hsp90 inhibitors as novel cancer chemotherapeutic agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709180105

Timing requirements for insulin/IGF-1 signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709180105

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709180105

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709180105

Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265134

Hereditary leucodystrophy in the mouse: the new mutant twitcher

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18292230

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0709180105

1 reference

611398

ADS bibcode

2008PNAS..105.3622D

0 references

611398

1 reference

1 reference

1 reference