Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation (Q24296392)

2

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Yong-Jun Wang

3

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Hiroyuki Kaneki

4

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Lianping Xing

5

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Regis J O'keefe

6

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Di Chen

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

10 February 2006

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published in

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volume

281

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page(s)

3569-76

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issue

6

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cites work

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

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Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

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Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

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Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

19 March 2017

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

19 March 2017

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Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

19 March 2017

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

19 March 2017

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Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

7 April 2017

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Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo

27 September 2017

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Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo

27 September 2017

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Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

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E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

27 September 2017

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Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

27 September 2017

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Role of Runx genes in chondrocyte differentiation

27 September 2017

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runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins

27 September 2017

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Smad-Runx interactions during chondrocyte maturation

27 September 2017

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Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

27 September 2017

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Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

27 September 2017

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Cbfa1 is a positive regulatory factor in chondrocyte maturation

27 September 2017

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

27 September 2017

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Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.

27 September 2017

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

27 September 2017

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Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages

27 September 2017

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A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element

27 September 2017

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Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

27 September 2017

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Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues

27 September 2017

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Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family.

21 January 2018

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Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506761200

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506761200