The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability (Q24296476)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

12

Steven S Shen

0 references

Christopher R. Vakoc

object named as

Christopher Vakoc

10

0 references

Iannis Aifantis

14

object named as

Iannis Aifantis

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author name string

Bryan King

1

0 references

Thomas Trimarchi

2

0 references

Linsey Reavie

3

0 references

Luyao Xu

4

0 references

Jasper Mullenders

5

0 references

Panagiotis Ntziachristos

6

0 references

Beatriz Aranda-Orgilles

7

0 references

Arianne Perez-Garcia

8

0 references

Junwei Shi

9

0 references

Peter Sandy

11

0 references

Adolfo Ferrando

A landscape of driver mutations in melanoma

13

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language of work or name

English

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publication date

20 June 2013

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published in

Cell

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volume

153

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page(s)

1552-66

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issue

7

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cites work

1 reference

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Selective inhibition of BET bromodomains

19 March 2017

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Efficient tumour formation by single human melanoma cells

19 March 2017

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BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

19 March 2017

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c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

19 March 2017

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

19 March 2017

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An extended transcriptional network for pluripotency of embryonic stem cells

19 March 2017

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

19 March 2017

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

19 March 2017

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Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

19 March 2017

1 reference

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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

19 March 2017

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

19 March 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

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The mutational landscape of head and neck squamous cell carcinoma

7 April 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

7 April 2017

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Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

7 April 2017

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Inducible gene targeting in mice

7 April 2017

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Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

7 April 2017

1 reference

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Transcriptional amplification in tumor cells with elevated c-Myc.

27 September 2017

1 reference

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The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development

27 September 2017

1 reference

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SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

27 September 2017

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The Pediatric Cancer Genome Project

27 September 2017

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Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

27 September 2017

1 reference

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A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

27 September 2017

1 reference

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

27 September 2017

1 reference

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

27 September 2017

1 reference

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The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation

27 September 2017

1 reference

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Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

27 September 2017

1 reference

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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Igf1r as a therapeutic target in a mouse model of basal-like breast cancer

27 September 2017

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ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes

27 September 2017

1 reference

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Modelling Myc inhibition as a cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Molecular pathogenesis of T-cell leukaemia and lymphoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Fbw7/hCDC4 dimerization regulates its substrate interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Inactivation of hCDC4 can cause chromosomal instability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Gene expression profiling in T-cell acute lymphoblastic leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

More than just proliferation: Myc function in stem cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Gene expression profiles during human CD4+ T cell differentiation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4146439

Control of inducible gene expression by signal-dependent transcriptional elongation

29 November 2018

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Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2013.05.041

inferred from DOI database lookup

7 January 2021

based on heuristic

Tumor suppressor functions of FBW7 in cancer development and progression

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2013.05.041

inferred from DOI database lookup

7 January 2021

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Muscarinic agonists induce phosphorylation-independent activation of the NHE-1 isoform of the Na+/H+ antiporter in salivary acinar cells

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2013.05.041

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2013.05.041

1 reference

2052057

2052057

1 reference

1 reference

1 reference