The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia (Q36229601)

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2 January 2020

title

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia (English)

1 reference

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2 January 2020

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6

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2 January 2020

8

Iannis Aifantis

1 reference

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2 January 2020

author name string

Benjamin J Thompson

1

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2 January 2020

Silvia Buonamici

2

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2 January 2020

Maria Luisa Sulis

3

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2 January 2020

Teresa Palomero

4

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2 January 2020

Tomas Vilimas

5

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2 January 2020

Adolfo Ferrando

7

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2 January 2020

language of work or name

English

0 references

publication date

23 July 2007

1 reference

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Journal of Experimental Medicine

2 January 2020

published in

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2 January 2020

volume

204

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2 January 2020

issue

8

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2 January 2020

page(s)

1825-1835

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describes a project that uses

2 January 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

1 October 2017

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Mutation analysis of hCDC4 in AML cells identifies a new intronic polymorphism

1 October 2017

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

1 October 2017

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Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

1 October 2017

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

1 October 2017

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

1 October 2017

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

1 October 2017

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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

1 October 2017

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Activating Notch1 mutations in mouse models of T-ALL.

1 October 2017

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

1 October 2017

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Ras activity regulates cyclin E degradation by the Fbw7 pathway.

1 October 2017

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Regulation of the cell cycle by SCF-type ubiquitin ligases

1 October 2017

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.

1 October 2017

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Molecular genetics of T cell development

1 October 2017

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The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

1 October 2017

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

1 October 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 October 2017

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

1 October 2017

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

1 October 2017

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Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

1 October 2017

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

1 October 2017

1 reference

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

1 October 2017

1 reference

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 October 2017

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 October 2017

1 reference

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

1 October 2017

1 reference

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 October 2017

1 reference

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Notch signaling: cell fate control and signal integration in development

1 October 2017

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

1 October 2017

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A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes

1 October 2017

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Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.

1 October 2017

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CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability

29 June 2018

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22 September 2018

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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118676

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118676

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118676

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118676

Be13, a human T-leukemia cell line highly sensitive to dexamethasone-induced cytolysis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118676

Comparative sequence analysis of incomplete DJH and TCR gene rearrangements in children with relapses of T-ALL

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17646408

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20070872

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17646408%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17646408%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference