SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. (Q36033829)

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5 February 2020

title

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction (English)

1 reference

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5 February 2020

main subject

protein ubiquitination

1 reference

7

1 reference

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5 February 2020

10

Steven P Gygi

1 reference

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5 February 2020

12

John M Asara

1 reference

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5 February 2020

3

Hiroyuki Inuzuka

1 reference

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5 February 2020

15

Wenyi Wei

1 reference

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5 February 2020

6

Lixin Wan

1 reference

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5 February 2020

8

Shavali Shaik

1 reference

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5 February 2020

1

Hidefumi Fukushima

1 reference

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5 February 2020

author name string

Akinobu Matsumoto

2

1 reference

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5 February 2020

Bo Zhai

4

1 reference

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5 February 2020

Alan W Lau

5

1 reference

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5 February 2020

Min Yuan

9

1 reference

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5 February 2020

Eijiro Jimi

11

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5 February 2020

Keiko Nakayama

13

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Keiichi I Nakayama

14

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5 February 2020

publication date

1 May 2012

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5 February 2020

1 reference

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5 February 2020

volume

1

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5 February 2020

issue

5

1 reference

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5 February 2020

page(s)

434-443

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Inflammation meets cancer, with NF-κB as the matchmaker

5 February 2020

cites work

1 reference

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Crosstalk in NF-κB signaling pathways

2 October 2017

1 reference

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Hierarchies of NF-κB target-gene regulation

2 October 2017

1 reference

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Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

NF-κB, inflammation, and metabolic disease.

2 October 2017

1 reference

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Myc suppression of Nfkb2 accelerates lymphomagenesis

2 October 2017

1 reference

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Signaling to NF-kappaB: regulation by ubiquitination

2 October 2017

1 reference

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TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21

2 October 2017

1 reference

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Regulation and function of NF-kappaB transcription factors in the immune system

2 October 2017

1 reference

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Stabilization of RelB requires multidomain interactions with p100/p52.

2 October 2017

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

A fourth IkappaB protein within the NF-kappaB signaling module

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Circuitry of nuclear factor kappaB signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

The SCF ubiquitin ligase: insights into a molecular machine

2 October 2017

1 reference

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Inactivation of hCDC4 can cause chromosomal instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

2 October 2017

1 reference

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

2 October 2017

1 reference

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Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

2 October 2017

1 reference

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

2 October 2017

1 reference

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Rearranged NFKB-2 genes in lymphoid neoplasms code for constitutively active nuclear transactivators

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

The generation of nfkb2 p52: mechanism and efficiency

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375724

Chemical approaches to angiogenesis

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22708077

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22708077

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Negative regulation of TCR signaling by NF-kappaB2/p100

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22708077

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2012.04.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22708077%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22708077%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22708077%20AND%20SRC:MED&resulttype=core&format=json