Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors (Q24296595)

Wnt receptor catabolic process

1 reference

Ring finger protein 43

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Zinc and ring finger 3

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author

Hans Clevers

11

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Marc van de Wetering

6

Marc van de Wetering

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Teck Yew Low

4

Teck Y Low

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Daniel E Stange

Daniel E Stange

5

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Shabaz Mohammed

Shabaz Mohammed

8

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Madelon M Maurice

Madelon M Maurice

10

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Bon-Kyoung Koo

Bon-Kyoung Koo

1

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Ingrid Jordens

Ingrid Jordens

3

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Johan H. van Es

7

Johan H van Es

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author name string

Maureen Spit

2

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Albert J R Heck

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

9

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language of work or name

English

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publication date

30 August 2012

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published in

Nature

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volume

488

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issue

7413

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page(s)

665-9

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Identification of stem cells in small intestine and colon by marker gene Lgr5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Myc deletion rescues Apc deficiency in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Wnt signalling induces maturation of Paneth cells in intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Controlled gene expression in primary Lgr5 organoid cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

The role of ubiquitylation in receptor endocytosis and endosomal sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

The Intestinal Wnt/TCF Signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895187

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exome sequencing of liver fluke-associated cholangiocarcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895187

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11308

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

760483

1013338577

0 references

760483

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference