Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors (Q24296595)

Wnt receptor catabolic process

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Ring finger protein 43

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Zinc and ring finger 3

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author

Hans Clevers

11

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Marc van de Wetering

6

Marc van de Wetering

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Teck Yew Low

4

Teck Y Low

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Daniel E Stange

Daniel E Stange

5

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Shabaz Mohammed

Shabaz Mohammed

8

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Madelon M Maurice

Madelon M Maurice

10

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Bon-Kyoung Koo

Bon-Kyoung Koo

1

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Ingrid Jordens

Ingrid Jordens

3

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Johan H. van Es

7

Johan H van Es

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author name string

Maureen Spit

2

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Albert J R Heck

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

9

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language of work or name

English

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publication date

30 August 2012

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published in

Nature

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volume

488

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issue

7413

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page(s)

665-9

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cites work

1 reference

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

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Transcription factor achaete scute-like 2 controls intestinal stem cell fate

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

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Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

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Myc deletion rescues Apc deficiency in the small intestine

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Wnt signalling induces maturation of Paneth cells in intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11308

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

1 reference

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

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The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

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Controlled gene expression in primary Lgr5 organoid cultures

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A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

21 January 2018

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Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

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Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

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The role of ubiquitylation in receptor endocytosis and endosomal sorting

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Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

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The Intestinal Wnt/TCF Signature.

21 January 2018

1 reference

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

21 January 2018

1 reference

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DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

1 reference

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APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

21 January 2018

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

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Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

21 January 2018

1 reference

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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

21 January 2018

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Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

21 January 2018

1 reference

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Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

21 January 2018

1 reference

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A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895187

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exome sequencing of liver fluke-associated cholangiocarcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22895187