Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl (Q24302528)

CYLD lysine 63 deubiquitinase

GOA release 2020-03-11

1 reference

negative regulation of canonical Wnt signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

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8

Hans Clevers

Hans

Clevers

1 reference

9 December 2023

Madelon M Maurice

9

Madelon M

Maurice

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9 December 2023

Mariola J Edelmann

4

Mariola J

Edelmann

1 reference

9 December 2023

Benedikt M Kessler

7

Benedikt M

Kessler

1 reference

9 December 2023

Daniele V F Tauriello

1

Daniele V F

Tauriello

1 reference

9 December 2023

Andrea Haegebarth

2

Andrea

Haegebarth

1 reference

9 December 2023

Ineke Kuper

3

Ineke

Kuper

1 reference

9 December 2023

Marre Henraat

5

Marre

Henraat

1 reference

9 December 2023

Marijke R Canninga-van Dijk

6

Marijke R

The novel functions of ubiquitination in signaling

Canninga-van Dijk

1 reference

9 December 2023

language of work or name

English

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publication date

12 March 2010

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published in

Molecular Cell

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volume

37

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issue

5

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page(s)

607-19

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cites work

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Wnt/beta-catenin signaling in development and disease

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Regulation of planar cell polarity by Smurf ubiquitin ligases

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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

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Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

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The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

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A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

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A mechanism for Wnt coreceptor activation

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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Identification of the familial cylindromatosis tumour-suppressor gene

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Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

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Scratching the surface of skin development

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Direct activation of protein kinases by unanchored polyubiquitin chains

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The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

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Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

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The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

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Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1.

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Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

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Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.

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Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

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Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

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The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

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Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

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The dishevelled protein is modified by wingless signaling in Drosophila

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

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The Wnt signaling pathway in development and disease

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Modification of proteins by ubiquitin and ubiquitin-like proteins

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Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

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Dynamic recruitment of axin by Dishevelled protein assemblies

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The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles.

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Wnt/Frizzled signaling in hepatocellular carcinoma

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