Identification of HEXIM1 as a positive regulator of p53 (Q24297975)

positive regulation of signal transduction by p53 class mediator

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Qiao Jing Lew

1

Qiao Jing

Lew

1 reference

19 October 2023

Yi Ling Chia

2

Yi Ling

Chia

1 reference

19 October 2023

Kai Ling Chu

3

Kai Ling

Chu

1 reference

19 October 2023

Yuen Ting Lam

4

Yuen Ting

Lam

1 reference

19 October 2023

Meera Gurumurthy

5

Meera

Gurumurthy

1 reference

19 October 2023

Shengli Xu

6

Shengli

Xu

1 reference

19 October 2023

Kong Peng Lam

7

Kong Peng

Lam

1 reference

19 October 2023

Nge Cheong

8

Nge

Cheong

1 reference

19 October 2023

Sheng-Hao Chao

9

Sheng-Hao

Chao

1 reference

Journal of Biological Chemistry

19 October 2023

language of work or name

English

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publication date

19 October 2012

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published in

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volume

287

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issue

43

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page(s)

36443-54

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cites work

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

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Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

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MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

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Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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WAF1, a potential mediator of p53 tumor suppression

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

19 March 2017

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Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA

19 March 2017

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Controlling the elongation phase of transcription with P-TEFb

19 March 2017

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Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics

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Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

19 March 2017

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The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1

19 March 2017

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Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors

19 March 2017

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

19 March 2017

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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

19 March 2017

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Definition of a consensus binding site for p53

19 March 2017

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A chromatin landmark and transcription initiation at most promoters in human cells

19 March 2017

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

7 April 2017

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RNA polymerase is poised for activation across the genome

7 April 2017

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Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

7 April 2017

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NPMc(+) AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds.

7 April 2017

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HEXIM1 is a critical determinant of the response to tamoxifen

27 September 2017

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Pharmacologic activation of p53 by small-molecule MDM2 antagonists

27 September 2017

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CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration

27 September 2017

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27 September 2017

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Awakening guardian angels: drugging the p53 pathway

27 September 2017

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Ubiquitination of HEXIM1 by HDM2.

27 September 2017

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Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.

27 September 2017

1 reference

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Cdk9 phosphorylates p53 on serine 392 independently of CKII.

27 September 2017

1 reference

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Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Regulation of the cdk inhibitor p27 and its deregulation in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Regulation of the specific DNA binding function of p53

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Human cytomegalovirus: glycoproteins associated with virions and dense bodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.374157

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.374157

The C terminus of p53 binds the N-terminal domain of MDM2.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.374157

The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476310

Up-regulation of a mutant form of p53 by doxorubicin in human squamous carcinoma cells

29 November 2018

1 reference

12 December 2020

Inhibition of RNA polymerase II as a trigger for the p53 response

1 reference

12 December 2020

CDK9 phosphorylates p53 on serine residues 33, 315 and 392

1 reference

12 December 2020

Activation of P-TEFb induces p21 leading to cell cycle arrest

1 reference

12 December 2020

release_euq4b6othrc5tjwbhwjjdizj2i

Identifiers

DOI

10.1074/JBC.M112.374157

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Fatcat ID

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PMC publication ID

3476310

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