HEXIM P-TEFb complex subunit 1 (Q21114044)

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mammalian protein found in Homo sapiens
  • estrogen down-regulated gene 1 protein
  • hexamethylene-bis-acetamide-inducible transcript 1
  • cardiac lineage protein 1
  • HMBA-inducible
  • menage a quatre 1
  • protein HEXIM1
  • hexamethylene bisacetamide inducible 1
  • hexamthylene bis-acetamide inducible 1
  • menage a quatre protein 1
  • hexamethylene bisacetamide-inducible protein
  • hexamethylene bis-acetamide inducible 1
  • HEXIM1
  • hexamethylene bis-acetamide-inducible protein 1
  • HEXIM1 protein, human
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Language Label Description Also known as
English
HEXIM P-TEFb complex subunit 1
mammalian protein found in Homo sapiens
  • estrogen down-regulated gene 1 protein
  • hexamethylene-bis-acetamide-inducible transcript 1
  • cardiac lineage protein 1
  • HMBA-inducible
  • menage a quatre 1
  • protein HEXIM1
  • hexamethylene bisacetamide inducible 1
  • hexamthylene bis-acetamide inducible 1
  • menage a quatre protein 1
  • hexamethylene bisacetamide-inducible protein
  • hexamethylene bis-acetamide inducible 1
  • HEXIM1
  • hexamethylene bis-acetamide-inducible protein 1
  • HEXIM1 protein, human

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner
GOA
curator
UniProt
UniProt protein ID
O94992
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA
GOA
curator
UniProt
UniProt protein ID
O94992
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
retrieved
8 April 2019
stated in
Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94992
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
C476123
subject named as
HEXIM1 protein, human
0 references
 
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