Identification of novel VHL target genes and relationship to hypoxic response pathways (Q24299968)

Myosin light chain 2

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Von Hippel-Lindau tumor suppressor

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negative regulation of cell growth

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Rosamonde Elizabeth Banks

author

5

object named as

Rosamonde E Banks

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Claire Johnson

object named as

Claire M Johnson

7

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Eamonn R Maher

object named as

Eamonn R Maher

8

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author name string

Esther N Maina

1

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Mark R Morris

2

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Malgorzata Zatyka

3

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Raju R Raval

4

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Frances M Richards

Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

6

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language of work or name

English

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publication date

30 June 2005

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published in

Oncogene

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volume

24

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issue

28

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page(s)

4549-58

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cites work

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Matricellular proteins: extracellular modulators of cell function

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

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Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22

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Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

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Mutations of the VHL tumour suppressor gene in renal carcinoma

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

21 January 2018

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Quantitative reverse transcription-PCR measurement of tissue factor mRNA in glioma

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An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

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The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

21 January 2018

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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

21 January 2018

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Structure and chromosomal localization of mouse G protein subunit gamma 4 gene

21 January 2018

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Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

21 January 2018

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Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

21 January 2018

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SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells

21 January 2018

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Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein

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Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

21 January 2018

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

21 January 2018

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Beckwith-Wiedemann syndrome: imprinting in clusters revisited

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.

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Molecular cloning of differentially expressed genes in human epithelial ovarian cancer.

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

21 January 2018

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

21 January 2018

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SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix

21 January 2018

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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer

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Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas

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The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2

21 January 2018

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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

21 January 2018

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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

21 January 2018

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SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells

21 January 2018

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Down-Regulation of DOC-2 in Colorectal Cancer Points to Its Role as a Tumor Suppressor in This Malignancy

21 January 2018

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SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells

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inferred from DOI database lookup

7 January 2021

based on heuristic

Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208649

inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208649