Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex (Q24654714)

1

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T Kamura

3

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N Minato

4

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R C Conaway

5

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J W Conaway

6

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R D Klausner

7

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A Pause

Proceedings of the National Academy of Sciences of the United States of America

8

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language of work or name

English

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publication date

26 October 1999

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published in

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volume

96

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issue

22

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page(s)

12436-41

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cites work

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

7 April 2017

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

7 April 2017

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Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

7 April 2017

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

7 April 2017

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

7 April 2017

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

7 April 2017

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

7 April 2017

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

7 April 2017

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A new NEDD8-ligating system for cullin-4A

7 April 2017

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

7 April 2017

1 reference

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Twenty proteins containing a C-terminal SOCS box form five structural classes

7 April 2017

1 reference

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A new protein containing an SH2 domain that inhibits JAK kinases

7 April 2017

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A family of cytokine-inducible inhibitors of signalling

7 April 2017

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

7 April 2017

1 reference

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

7 April 2017

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

7 April 2017

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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

7 April 2017

1 reference

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Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

7 April 2017

1 reference

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Inhibition of transcription elongation by the VHL tumor suppressor protein

7 April 2017

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7 April 2017

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

7 April 2017

1 reference

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

A novel protein modification pathway related to the ubiquitin system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Ubiquitin-dependent protein degradation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

7 April 2017

https://api.crossref.org/works/10.1073%2FPNAS.96.22.12436

7 January 2021

inferred from DOI database lookup

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Structure and function of a new STAT-induced STAT inhibitor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The ubiquitin-proteasome proteolytic pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The von Hippel-Lindau tumour suppressor protein: new perspectives

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

How the cyclin became a cyclin: regulated proteolysis in the cell cycle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The oncogenic activation of beta-catenin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Tumour suppression by the human von Hippel-Lindau gene product

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Proteolysis and the G1-S transition: the SCF connection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

Mutations of the VHL tumour suppressor gene in renal carcinoma

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

The Elongin BC complex and the von Hippel-Lindau tumor suppressor protein.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22941

von Hippel-Lindau disease

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10535940

12 December 2020

inferred from PubMed ID database lookup

The VHL tumour-suppressor gene paradigm

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10535940

12 December 2020

inferred from PubMed ID database lookup

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10535940

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.96.22.12436

1 reference

3274205

ADS bibcode

1999PNAS...9612436I

0 references

3274205

1 reference

1 reference

1 reference