Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus (Q24300692)

DDB1 and CUL4 associated factor 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Hediye Erdjument-Bromage

11

0 references

Paul Tempst

13

0 references

Wei Li

1

object named as

Wei Li

0 references

Ryohei Ishii

object named as

Ryohei Ishii

7

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author name string

Liru You

2

0 references

Jonathan Cooper

3

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Gaia Schiavon

4

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Angela Pepe-Caprio

5

0 references

Lu Zhou

6

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Marco Giovannini

8

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C Oliver Hanemann

9

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Stephen B Long

10

0 references

Pengbo Zhou

12

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Filippo G Giancotti

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

14

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language of work or name

English

0 references

publication date

19 February 2010

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published in

Cell

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volume

140

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page(s)

477-90

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issue

4

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cites work

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

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Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling

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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development

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27 September 2017

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

30 May 2018

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Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

30 May 2018

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Identifiers

DOI

1 reference

3098174

3098174

1 reference

1 reference

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