The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation (Q35853950)

10 August 2017

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title

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation (English)

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10 August 2017

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Stephen S Taylor

1

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author name string

Maria I F Scott

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2

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PubMed ID

15289666

10 August 2017

Andrew J Holland

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3

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10 August 2017

1 January 2004

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10 August 2017

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10 August 2017

12

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10 August 2017

6

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10 August 2017

599-616

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https://scigraph.springernature.com/pub.10.1023/b:chro.0000036610.78380.51

10 August 2017

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cites work

The mouse Mps1p-like kinase regulates centrosome duplication

1 reference

12 December 2020

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

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12 December 2020

Chromosomal cohesin forms a ring

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12 December 2020

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

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12 December 2020

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

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12 December 2020

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

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12 December 2020

Segregating sister genomes: the molecular biology of chromosome separation

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12 December 2020

The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins

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12 December 2020

CENP-E as an essential component of the mitotic checkpoint in vitro.

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12 December 2020

Budding yeast Cdc20: a target of the spindle checkpoint.

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12 December 2020

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

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12 December 2020

Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast

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12 December 2020

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

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12 December 2020

Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.

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12 December 2020

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

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12 December 2020

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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12 December 2020

Suspended Animation in C. elegans Requires the Spindle Checkpoint

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12 December 2020

Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E

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12 December 2020

Recycling the Cell Cycle

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12 December 2020

Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins.

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12 December 2020

Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.

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12 December 2020

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis

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12 December 2020

Aneuploid colon cancer cells have a robust spindle checkpoint

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12 December 2020

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

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12 December 2020

Feedback control of mitosis in budding yeast

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12 December 2020

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

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12 December 2020

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

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12 December 2020

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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12 December 2020

Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe.

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12 December 2020

The Spindle Assembly and Spindle Position Checkpoints

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12 December 2020

A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells

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12 December 2020

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

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12 December 2020

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

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12 December 2020

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

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12 December 2020

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

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12 December 2020

How cells get the right chromosomes

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12 December 2020

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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12 December 2020

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

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12 December 2020

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

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12 December 2020

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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12 December 2020

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

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12 December 2020

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

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12 December 2020

Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

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12 December 2020

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

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12 December 2020

An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells

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12 December 2020

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase

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12 December 2020

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

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12 December 2020

Cdc20 associates with the kinase aurora2/Aik

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12 December 2020

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

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12 December 2020

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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12 December 2020

Mitotic forces control a cell-cycle checkpoint

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12 December 2020

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

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12 December 2020

Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint

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12 December 2020

Nup358 integrates nuclear envelope breakdown with kinetochore assembly

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12 December 2020

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

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12 December 2020

Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner

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12 December 2020

The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

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12 December 2020

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC

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12 December 2020

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

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12 December 2020

Mutations in the APC tumour suppressor gene cause chromosomal instability

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12 December 2020

The spindle checkpoint: structural insights into dynamic signalling

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12 December 2020

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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12 December 2020

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

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12 December 2020

Checkpoints: controls that ensure the order of cell cycle events

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12 December 2020

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

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12 December 2020

The mitotic spindle: a self-made machine

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12 December 2020

The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.

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12 December 2020

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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12 December 2020

Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs

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12 December 2020

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

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12 December 2020

Genetic instability in colorectal cancers

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12 December 2020

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint.

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12 December 2020

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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12 December 2020

Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

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12 December 2020

Suppression of centromere dynamics by Taxol in living osteosarcoma cells.

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12 December 2020

Identification of a MAD2-binding protein, CMT2, and its role in mitosis

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12 December 2020

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

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12 December 2020

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast

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12 December 2020

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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12 December 2020

The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.

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12 December 2020

The Ran GTPase regulates kinetochore function

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12 December 2020

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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12 December 2020

Mutations of mitotic checkpoint genes in human cancers

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12 December 2020

Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint

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12 December 2020

Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells

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12 December 2020

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

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12 December 2020

Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells

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12 December 2020

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

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12 December 2020

NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae

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12 December 2020

Identification of a human mitotic checkpoint gene: hsMAD2

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12 December 2020

The spindle checkpoint

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12 December 2020

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

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12 December 2020

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

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12 December 2020

Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

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12 December 2020

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

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12 December 2020

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

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12 December 2020

A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans

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12 December 2020

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

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12 December 2020

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

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12 December 2020

Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase

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12 December 2020

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint

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12 December 2020

The anaphase-promoting complex: proteolysis in mitosis and beyond

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12 December 2020

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

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12 December 2020

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

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12 December 2020

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

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12 December 2020

Chromosome micromanipulation. 3. Spindle fiber tension and the reorientation of mal-oriented chromosomes

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12 December 2020

Structural and mechanical control of mitotic progression

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12 December 2020

Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

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12 December 2020

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

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12 December 2020

Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen.

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12 December 2020

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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12 December 2020

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

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12 December 2020

Distinct chromosome segregation roles for spindle checkpoint proteins

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12 December 2020

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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12 December 2020

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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12 December 2020

Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

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12 December 2020

Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest

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12 December 2020

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

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12 December 2020

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

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12 December 2020

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

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12 December 2020

Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

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12 December 2020

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

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12 December 2020

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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12 December 2020

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

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12 December 2020

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

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12 December 2020

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

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12 December 2020

Recycling the cell cycle: cyclins revisited

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12 December 2020

10.1023/B:CHRO.0000036610.78380.51

Identifiers

DOI

1 reference

PubMed ID

15289666

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15289666