STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis (Q24300906)

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English	STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis	scientific article

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scholarly article

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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis (English)

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based on heuristic

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author name string

Ying Dunkel

1

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Andrew Ong

2

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Dimple Notani

3

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Yash Mittal

4

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Michael Lam

5

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Xiaoyi Mi

6

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Pradipta Ghosh

7

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language of work or name

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publication date

7 December 2012

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Journal of Biological Chemistry

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287

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50

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41667-83

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3516717/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Akt/PKB regulates actin organization and cell motility via Girdin/APE

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Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

1 reference

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Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway

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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

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Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer

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1 reference

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1 reference

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Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

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Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

1 reference

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STAT3 as a central regulator of tumor metastases

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1 reference

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GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling

1 reference

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Activation of Galphai3 triggers cell migration via regulation of GIV.

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1 reference

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1 reference

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Stat3 regulates genes common to both wound healing and cancer

1 reference

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

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1 reference

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Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1.

1 reference

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The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

1 reference

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Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants

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Human skin transcriptome during superficial cutaneous wound healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516717

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The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

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based on heuristic

inferred from PubMed ID database lookup

Clinical implications for girdin protein expression in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Girdin protein: a new potential distant metastasis predictor of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimer stability as a determinant of differential DNA binding activity of Stat3 isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

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Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23066027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M112.390781

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