Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy (Q37869903)

24 August 2017

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title

Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy (English)

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24 August 2017

Arianna Gelain

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Stefania Villa

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Stefania Villa

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Fiorella Meneghetti

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Fiorella Meneghetti

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author name string

Daniela Masciocchi

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PubMed ID

21526897

24 August 2017

Daniela Barlocco

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PubMed ID

21526897

24 August 2017

language of work or name

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1 April 2011

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

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24 August 2017

5

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24 August 2017

567-597

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STATs and gene regulation

24 August 2017

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The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

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Transcription factors as targets for cancer therapy

21 January 2018

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The STATs of cancer--new molecular targets come of age

21 January 2018

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Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing

21 January 2018

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Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

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Regulation of gene-activation pathways by PIAS proteins in the immune system

21 January 2018

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Negative regulation of cytokine signaling pathways

21 January 2018

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Control mechanism of JAK/STAT signal transduction pathway

21 January 2018

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Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

21 January 2018

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SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling

21 January 2018

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Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

21 January 2018

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

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Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

21 January 2018

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The competitive binding of STAT3 and NF-kappaB on an overlapping DNA binding site

21 January 2018

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

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Does the immune system see tumors as foreign or self?

21 January 2018

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

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A critical role for Stat3 signaling in immune tolerance

21 January 2018

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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

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Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

21 January 2018

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

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Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

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Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

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Mechanisms of apoptosis by c-Myc

21 January 2018

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

21 January 2018

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Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

21 January 2018

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21 January 2018

Surfing the p53 network

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21 January 2018

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STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Oncogenes and angiogenesis: signaling three-dimensional tumor growth

21 January 2018

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

21 January 2018

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Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3.

21 January 2018

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21 January 2018

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STAT3 as a target for inducing apoptosis in solid and hematological tumors

21 January 2018

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STAT proteins: novel molecular targets for cancer drug discovery

21 January 2018

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

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Stats: transcriptional control and biological impact

21 January 2018

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Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

21 January 2018

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STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription

21 January 2018

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STAT 3 as a target for cancer drug discovery

21 January 2018

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

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Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

21 January 2018

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Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

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Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition

21 January 2018

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A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity

21 January 2018

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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

21 January 2018

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Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

21 January 2018

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Regulation of cytokine signaling pathways by PIAS proteins

21 January 2018

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The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death

21 January 2018

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Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

21 January 2018

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Structural basis for the binding of high affinity phosphopeptides to Stat3.

21 January 2018

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A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

21 January 2018

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Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

21 January 2018

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Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

21 January 2018

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Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

21 January 2018

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Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

21 January 2018

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Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3

21 January 2018

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Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

21 January 2018

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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells

21 January 2018

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Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

21 January 2018

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Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders

21 January 2018

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An unnatural amino acid that mimics phosphotyrosine.

21 January 2018

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

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A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 January 2018

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

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LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

21 January 2018

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Design, synthesis, and studies of small molecule STAT3 inhibitors

21 January 2018

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A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

21 January 2018

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Novel high-throughput screening system for identifying STAT3-SH2 antagonists

21 January 2018

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Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

21 January 2018

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Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

21 January 2018

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Chemical probes that competitively and selectively inhibit Stat3 activation

21 January 2018

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Identification of a New Series of STAT3 Inhibitors by Virtual Screening

21 January 2018

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G-quartet structures in telomeric DNA.

21 January 2018

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Quadruplex DNA: sequence, topology and structure

21 January 2018

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Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer

21 January 2018

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A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

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Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing.

21 January 2018

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Role of STAT3 decoy oligodeoxynucleotides on cell invasion and chemosensitivity in human epithelial ovarian cancer cells

21 January 2018

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Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional Chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 cells

21 January 2018

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Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin

21 January 2018

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Interaction of the chemopreventive agent resveratrol and its metabolite, piceatannol, with model membranes.

21 January 2018

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Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol

21 January 2018

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Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

21 January 2018

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17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

21 January 2018

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5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization

21 January 2018

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Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells

21 January 2018

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Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation.

21 January 2018

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Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose.

21 January 2018

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Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo.

21 January 2018

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Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells

21 January 2018

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Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity

21 January 2018

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Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways

21 January 2018

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Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells

21 January 2018

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Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

21 January 2018

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Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

21 January 2018

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MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

21 January 2018

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A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells

21 January 2018

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TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients

21 January 2018

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Epigenetic therapy of lymphoma using histone deacetylase inhibitors

21 January 2018

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Therapeutic potential of JAK2 inhibitors

21 January 2018

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Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells

21 January 2018

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

21 January 2018

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Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

21 January 2018

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CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

21 January 2018

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Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

21 January 2018

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Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells

21 January 2018

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Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells

21 January 2018

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Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs

21 January 2018

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Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3

21 January 2018

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Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding

21 January 2018

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Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors

21 January 2018

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Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

21 January 2018

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Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases

21 January 2018

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STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

21 January 2018

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Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

21 January 2018

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Satraplatin: leading the new generation of oral platinum agents

21 January 2018

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Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line

21 January 2018

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Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells

21 January 2018

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Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells

21 January 2018

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12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s)

21 January 2018

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ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

21 January 2018

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The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells

21 January 2018

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HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling

21 January 2018

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Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

21 January 2018

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Enalapril alters expression of key growth factors in experimental diabetic retinopathy

21 January 2018

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Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3.

21 January 2018

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Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance

21 January 2018

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Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

21 January 2018

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A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells

21 January 2018

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Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma

21 January 2018

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NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts

21 January 2018

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Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation

21 January 2018

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Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway

21 January 2018

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The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity

21 January 2018

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The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.11.22

1 reference

24 August 2017

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PubMed ID

21526897