Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors (Q33959754)

30 July 2017

1 reference

title

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors (English)

1 reference

30 July 2017

Florian R Greten

2

0 references

author name string

Arun K Mankan

series ordinal

1

1 reference

PubMed ID

21751940

30 July 2017

language of work or name

English

0 references

publication date

14 July 2011

1 reference

Expert Opinion on Investigational Drugs

30 July 2017

1 reference

30 July 2017

20

1 reference

30 July 2017

9

1 reference

30 July 2017

1263-1275

1 reference

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

30 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STATs and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STATs: signal transducers and activators of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The STATs of cancer--new molecular targets come of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

JAK-STAT signaling: from interferons to cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT family of transcription factors in cytokine-mediated biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Control of myeloid differentiation and survival by Stats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Stat5a/b are essential for normal lymphoid development and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Stats: transcriptional control and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Getting the message across, STAT! Design principles of a molecular signaling circuit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Specific inhibition of Stat3 signal transduction by PIAS3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibition of Stat1-mediated gene activation by PIAS1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT signaling is active during early mammalian development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT3 as a target for inducing apoptosis in solid and hematological tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Nucleocytoplasmic shuttling of persistently activated STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Identification of a nuclear Stat1 protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The function of Stat3 in tumor cells and their microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Physical and functional interactions between STAT3 and KAP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Activation and association of Stat3 with Src in v-Src-transformed cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Interleukin-11 up-regulates survivin expression in endothelial cells through a signal transducer and activator of transcription-3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Regulation of Stat3 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT3: a critical transcription activator in angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Function of mitochondrial Stat3 in cellular respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Rheumatoid arthritis synoviocyte survival is dependent on Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The role of apoptosis in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Immunity, Inflammation, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Human Th17 cells can be induced through head and neck cancer and have a functional impact on HNSCC development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT3 mutations in the hyper-IgE syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

STAT proteins: novel molecular targets for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Natural products in the process of finding new drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Small molecule inhibitors of Stat3 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

A role for JAK2 mutations in myeloproliferative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Peering into the aftermath: JAKi rips STAT3 in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Significance of interleukin-6 (IL-6) in breast cancer (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Serum interleukin-6 levels in colorectal cancer patients--a summary of published results

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.601739

10.1517/13543784.2011.601739

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

21751940