SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death (Q24301299)

TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

GOA release 2020-03-11

1 reference

protein localization to nucleus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Florian Renner

1

Florian

Renner

1 reference

PubMed

PubMed publication ID

20188669

20 April 2024

Rita Moreno

series ordinal

2

author given names

Rita

author last names

Moreno

1 reference

PubMed

PubMed publication ID

20188669

20 April 2024

M Lienhard Schmitz

series ordinal

3

author given names

M Lienhard

author last names

Schmitz

1 reference

PubMed

PubMed publication ID

20188669

The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

20 April 2024

language of work or name

English

0 references

publication date

26 February 2010

0 references

published in

Molecular Cell

0 references

volume

37

0 references

issue

4

0 references

page(s)

503-15

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Many faces of NF-kappaB signaling induced by genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Macromolecular crowding and its potential impact on nuclear function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

NF-kappaB activation by double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

PIDD mediates NF-kappaB activation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Shared principles in NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

The protein kinase IKKepsilon regulates energy balance in obese mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

The mechanisms of PML-nuclear body formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

The DNA damage response: ten years after

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

An E3-like factor that promotes SUMO conjugation to the yeast septins

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

PML is a direct p53 target that modulates p53 effector functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Atmospheric carbon dioxide concentrations over the past 60 million years

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

The function of PML in p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

1 reference

7 January 2021

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Principles of ubiquitin and SUMO modifications in DNA repair.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Molecular mimicry of SUMO promotes DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Regulation of apoptosis by PML and the PML-NBs.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Signals from within: the DNA-damage-induced NF-kappaB response

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Specification of SUMO1- and SUMO2-interacting motifs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

SUMOylation and De-SUMOylation: wrestling with life's processes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Deconstructing PML-induced premature senescence

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Beyond IkappaBs: alternative regulation of NF-kappaB activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Triggering the interferon antiviral response through an IKK-related pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Regulation and function of IKK and IKK-related kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Outcomes of p53 activation--spoilt for choice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021

Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.01.018

7 January 2021