The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells (Q24301738)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

Delta like non-canonical Notch ligand 2

12 March 2020

main subject

1 reference

Delta like non-canonical Notch ligand 1

GOA release 2020-03-11

1 reference

negative regulation of Notch signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Victoriano Baladrón

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

María-Luisa Nueda

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Ana-Isabel Naranjo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Jorge Laborda

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

English

0 references

publication date

2 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

number of pages

11

1 reference

Biochimica et Biophysica Acta

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

1843

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

2674-2684

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

Notch: Implications of endogenous inhibitors for therapy

12 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch inhibition as a promising new approach to cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Possible roles of DLK1 in the Notch pathway during development and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch signaling: emerging molecular targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Targeting notch signaling pathway in cancer: clinical development advances and challenges

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The double-edged sword of Notch signaling in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The many facets of Notch ligands

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Dlk1 in normal and abnormal hematopoiesis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

DLK1: increased expression in gliomas and associated with oncogenic activities.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Suppression of colon carcinogenesis by targeting Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Identification of new genes associated with melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Active Notch1 confers a transformed phenotype to primary human melanocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch1 is an effector of Akt and hypoxia in melanoma development

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Recent insights into the role of Notch signaling in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch signaling in development and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The molecular logic of Notch signaling--a structural and biochemical perspective.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch signaling proteins: legitimate targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

The effects of nutrient depleted microenvironments and delta-like 1 homologue (DLK1) on apoptosis in neuroblastoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.BBAMCR.2014.07.015

7 January 2021

10.1016/J.BBAMCR.2014.07.015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25093684%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference