dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. (Q40470678)

20 September 2017

dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. (English)

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20 September 2017

1

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José Javier García Ramírez

20 September 2017

5

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María José M Díaz-Guerra

4

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author name string

María José Ruiz-Hidalgo

2

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20 September 2017

María Luisa Nueda

3

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20 September 2017

Ezio Bonvini

6

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20 September 2017

Elena Gubina

7

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20 September 2017

Jorge Laborda

8

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20 September 2017

language of work or name

English

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publication date

2 November 2004

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Experimental Cell Research

20 September 2017

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20 September 2017

303

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20 September 2017

2

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20 September 2017

343-359

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Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2

20 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Molecular mechanisms of adipocyte differentiation and inhibitory action of pref-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch signaling: cell fate control and signal integration in development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

dlk modulates mitogen-activated protein kinase signaling to allow or prevent differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

A role for pref-1 and HES-1 in thymocyte development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Implication of ZOG protein (zona glomerulosa-specific protein) in zone development of the adrenal cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Pref-1, SF-1 and adrenocortical zonation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The homeotic protein dlk is expressed during peripheral nerve development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Specific regions of the extracellular domain of dlk, an EGF-like homeotic protein involved in differentiation, participate in intramolecular interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

SAGE analysis of neuroblastoma reveals a high expression of the human homologue of the Drosophila Delta gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch signalling in Drosophila: three ways to use a pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch pathway: making sense of suppressor of hairless

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Structural conservation of Notch receptors and ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Human ligands of the Notch receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Functional diversity among Notch1, Notch2, and Notch3 receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch signaling in vascular development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch-induced proteolysis and nuclear localization of the Delta ligand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Down-regulation of Delta by proteolytic processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Notch1 receptor is cleaved constitutively by a furin-like convertase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Muscarinic agonists induce phosphorylation-independent activation of the NHE-1 isoform of the Na+/H+ antiporter in salivary acinar cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Arbiter of differentiation and death: Notch signaling meets apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch1 functions as a tumor suppressor in mouse skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The p53 family member genes are involved in the Notch signal pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Human deltex is a conserved regulator of Notch signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch inhibition of E47 supports the existence of a novel signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Tat protein of the caprine arthritis encephalitis virus interacts with the Notch2 EGF-like repeats and the epithelin/granulin precursor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch signaling in T cell development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch and the immune system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Glycosylation analysis and protein structure determination of murine fetal antigen 1 (mFA1)--the circulating gene product of the delta-like protein (dlk), preadipocyte factor 1 (Pref-1) and stromal-cell-derived protein 1 (SCP-1) cDNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch 1 impairs osteoblastic cell differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Ras/MAPK cascade and the control of positive selection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Regulation of T cell fate by Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Distinct transcriptional profiles of adipogenesis in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Numb antagonizes Notch signaling to specify sibling neuron cell fates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Interactions between fibroblast growth factors and Notch regulate neuronal differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch signaling: Fringe really is a glycosyltransferase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Fringe is a glycosyltransferase that modifies Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Fringe forms a complex with Notch

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.001

10.1016/J.YEXCR.2004.10.001

7 January 2021

Identifiers

DOI

1 reference

20 September 2017

1 reference