Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. (Q36024533)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Therapeutic approaches to modulating Notch signaling: current challenges and future prospects (English)

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22 January 2020

1

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22 January 2020

author name string

Mark E Fortini

series ordinal

2

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22 January 2020

publication date

30 January 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

Seminars in Cell & Developmental Biology

22 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

23

1 reference

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22 January 2020

issue

4

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22 January 2020

page(s)

465-472

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

γ-Secretase inhibitors and modulators for Alzheimer's disease

22 January 2020

cites work

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2 October 2017

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2 October 2017

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The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

2 October 2017

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Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.

2 October 2017

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2 October 2017

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gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

2 October 2017

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

2 October 2017

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2 October 2017

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Rational targeting of Notch signaling in cancer

2 October 2017

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A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

2 October 2017

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2 October 2017

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Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

2 October 2017

1 reference

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CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors

2 October 2017

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Aberrant activation of notch signaling in human breast cancer

2 October 2017

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Activating Notch1 mutations in mouse models of T-ALL.

2 October 2017

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High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

2 October 2017

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Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

2 October 2017

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

2 October 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

2 October 2017

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

2 October 2017

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Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

2 October 2017

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Notch in lung development and lung cancer

2 October 2017

1 reference

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Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium

2 October 2017

1 reference

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Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

2 October 2017

1 reference

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Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

2 October 2017

1 reference

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

2 October 2017

1 reference

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Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

2 October 2017

1 reference

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Stem cells in normal breast development and breast cancer

2 October 2017

1 reference

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Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

2 October 2017

1 reference

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Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

2 October 2017

1 reference

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Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Notch signaling induces cell cycle arrest in small cell lung cancer cells

2 October 2017

1 reference

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Cell cycle arrest and apoptosis induced by Notch1 in B cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Involvement of Notch1 in the development of mouse mammary tumors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Notch inhibition blocks multiple myeloma cell-induced osteoclast activation

5 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372654

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells

5 December 2018

1 reference

12 December 2020

JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

12 December 2020

Chromosome 19 translocation, overexpression of Notch3, and human lung cancer

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

1 reference

12 December 2020

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase

1 reference

12 December 2020

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

1 reference

12 December 2020

Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma

1 reference

12 December 2020

10.1016/J.SEMCDB.2012.01.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22309842%20AND%20SRC:MED&resulttype=core&format=json