Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction (Q24302447)

negative regulation of myeloid cell differentiation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Sten Eirik W Jacobsen

3

object named as

S E W Jacobsen

0 references

Claus Nerlov

5

object named as

C Nerlov

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author name string

T Fujimoto

1

0 references

K Anderson

2

0 references

S-I Nishikawa

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

4

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language of work or name

English

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publication date

2 May 2007

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published in

The EMBO Journal

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volume

26

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issue

9

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page(s)

2361-70

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cites work

1 reference

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19 March 2017

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Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)

19 March 2017

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Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4

19 March 2017

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

19 March 2017

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19 March 2017

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Rb interacts with histone deacetylase to repress transcription

19 March 2017

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The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

19 March 2017

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Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

19 March 2017

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

19 March 2017

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Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

19 March 2017

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Oncogenic potential of the RUNX gene family: 'overview'.

27 September 2017

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C/EBPalpha mutations in acute myeloid leukaemias

27 September 2017

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

27 September 2017

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GATA-1-mediated proliferation arrest during erythroid maturation.

27 September 2017

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Disruption of differentiation in human cancer: AML shows the way.

27 September 2017

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The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

27 September 2017

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C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription

27 September 2017

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Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

27 September 2017

1 reference

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E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation

27 September 2017

1 reference

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

27 September 2017

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Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters

27 September 2017

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27 September 2017

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Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

27 September 2017

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Reciprocal regulation of adipogenesis by Myc and C/EBP alpha

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864973

Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864973

Step-wise divergence of primitive and definitive haematopoietic and endothelial cell lineages during embryonic stem cell differentiation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864973

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864973

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17431401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vivo self-renewal of c-Kit+ Sca-1+ Lin(low/-) hemopoietic stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17431401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cbfa1 in bone development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17431401