Oncogenic potential of the RUNX gene family: 'overview'. (Q35779678)

10 August 2017

title

Oncogenic potential of the RUNX gene family: 'overview'. (English)

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10 August 2017

Yoshiaki Ito

1

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

volume

23

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10 August 2017

issue

24

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10 August 2017

page(s)

4198-4208

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Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

10 August 2017

cites work

1 reference

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The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

21 January 2018

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Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta

21 January 2018

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

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Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

21 January 2018

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AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element

21 January 2018

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Solution structure of core binding factor beta and map of the CBF alpha binding site

21 January 2018

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RUNX transcription factors as key targets of TGF-beta superfamily signaling

21 January 2018

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

21 January 2018

1 reference

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AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

21 January 2018

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A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

21 January 2018

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

21 January 2018

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Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

21 January 2018

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Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

21 January 2018

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The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

21 January 2018

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The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

21 January 2018

1 reference

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

21 January 2018

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

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A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

RTCGD: retroviral tagged cancer gene database

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Polyoma regulatory region: a potential probe for mouse cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The RUNX3 gene--sequence, structure and regulated expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cancer genes come of age

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The Runx genes as dominant oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

A bumper crop of cancer genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

TGF-beta signaling in tumor suppression and cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Functional dissection of the alpha and beta subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The Runt domain identifies a new family of heteromeric transcriptional regulators.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Expression of polyoma early functions in mouse embryonal carcinoma cells depends on sequence rearrangements in the beginning of the late region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Specification of Drosophila hematopoietic lineage by conserved transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Causal relationship between the loss of RUNX3 expression and gastric cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Oncogenic transcription factors in the human acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The expression of SpRunt during sea urchin embryogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

NeW wrinkles for an old domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Isolation and characterization of polyoma virus mutants which grow in murine embryonal carcinoma and trophoblast cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Control of gut differentiation and intestinal-type gastric carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207755

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207755

1 reference

Dimensions Publication ID

10 August 2017

1043882645

0 references

1 reference