Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 (Q24303428)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21577200%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 (English)

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1 February 2020

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4

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1 February 2020

author name string

C Li

1

1 reference

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1 February 2020

J Ao

2

1 reference

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1 February 2020

J Fu

3

1 reference

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1 February 2020

J Xu

5

1 reference

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1 February 2020

D Lonard

6

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1 February 2020

B W O'Malley

7

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1 February 2020

language of work or name

English

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publication date

16 May 2011

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1 February 2020

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1 February 2020

volume

30

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issue

42

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1 February 2020

page(s)

4350-4364

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Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

1 February 2020

cites work

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Critical role for Daxx in regulating Mdm2

19 March 2017

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The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome

19 March 2017

1 reference

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SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

19 March 2017

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Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

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19 March 2017

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RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

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GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors

19 March 2017

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

19 March 2017

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Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

19 March 2017

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Function and regulation of cullin-RING ubiquitin ligases

19 March 2017

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The coregulator exchange in transcriptional functions of nuclear receptors

19 March 2017

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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

19 March 2017

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Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu

19 March 2017

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19 March 2017

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Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors

19 March 2017

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The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

19 March 2017

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Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits

19 March 2017

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AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

19 March 2017

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19 March 2017

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

19 March 2017

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27 September 2017

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27 September 2017

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Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover

27 September 2017

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The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

27 September 2017

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Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

27 September 2017

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Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

27 September 2017

1 reference

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Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate.

27 September 2017

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Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway

27 September 2017

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SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock

27 September 2017

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An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response

27 September 2017

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Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover

27 September 2017

1 reference

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Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway

27 September 2017

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Identification of substrates for F-box proteins

27 September 2017

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SRC-3 is required for prostate cancer cell proliferation and survival

27 September 2017

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Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.

27 September 2017

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Candidate target genes for loss of heterozygosity on human chromosome 17q21

27 September 2017

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ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance

27 September 2017

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Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth

27 September 2017

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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

27 September 2017

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Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer

27 September 2017

1 reference

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Phosphorylation and regulation of beta-catenin by casein kinase I epsilon

27 September 2017

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AIB1 enhances estrogen-dependent induction of cyclin D1 expression

27 September 2017

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Regulation of somatic growth by the p160 coactivator p/CIP

27 September 2017

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Mutation analysis of the BRCA1 gene in 23 families with cases of cancer of the breast, ovary, and multiple other sites

27 September 2017

1 reference

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Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q.

27 September 2017

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Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle

27 September 2017

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Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

30 May 2018

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The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.

21 January 2018

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AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice

21 January 2018

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BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

21 January 2018

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Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

21 January 2018

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17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification

21 January 2018

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The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

21 January 2018

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High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

21 January 2018

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BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

21 January 2018

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Evidence of chromosome regions and gene involvement in inflammatory breast cancer

31 March 2020

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RAC-3 is a NF-kappa B coactivator

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.151

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21577200%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 February 2020

1008108843

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21577200%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

2 references

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